The process of bone remodeling is the result of the regulated balance between bone cell
populations, namely bone-forming osteoblasts, bone-resorbing osteoclasts, and the …

The balance between bone forming cells (osteoblasts/osteocytes) and bone resorbing cells
(osteoclasts) plays a crucial role in tissue homeostasis and bone repair. Several hormones …

Abstract Purpose of Review Postmenopausal osteoporosis reduces circulating estrogen
levels, which leads to osteoclast resorption, bone loss, and fracture. This review addresses …

The discovery that two rare autosomal recessive high bone mass conditions were caused by
the loss of sclerostin expression prompted studies into its role in bone homeostasis. In this …

Osteocytes, the most abundant bone cell in the adult skeleton, can function as
mechanosensors directing osteoblast and osteoclast function in order to maintain optimal …

Bone homeostasis is a dynamic equilibrium between bone-forming osteoblasts and bone-
resorbing osteoclasts. This process is primarily controlled by the most abundant and …

Osteocyte produced fibroblast growth factor 23 (FGF23) is the key regulator of serum
phosphate (Pi) homeostasis. The interplay between parathyroid hormone (PTH), FGF23 and …

As the population of western societies on average ages, the number of people affected by
bone remodeling-associated diseases such as osteoporosis continues to increase. The …

Abstract Purpose of Review Osteocytes comprise> 95% of the cellular component in bone
tissue and produce a wide range of cytokines and cellular signaling molecules in response …

Purpose The purpose of this observational study was to investigate the effectiveness and
safety of romosozumab (ROMO) and teriparatide (TPTD) in a clinical setting. Methods A total …