Hydrogen sulfide (H2S) metabolism in mitochondria and its regulatory role in energy production

M Fu, W Zhang, L Wu, G Yang, H Li… - Proceedings of the …, 2012 - National Acad Sciences
Although many types of ancient bacteria and archea rely on hydrogen sulfide (H2S) for their
energy production, eukaryotes generate ATP in an oxygen-dependent fashion. We …

Antioxidants reduce cellular and functional changes induced by intense noise in the inner ear and cochlear nucleus

J Lu, W Li, X Du, DL Ewert, MB West, C Stewart… - Journal of the …, 2014 - Springer
The present study marks the first evaluation of combined application of the antioxidant N-
acetylcysteine (NAC) and the free radical spin trap reagent, disodium 2, 4-disulfophenyl-N …

Contribution of cysteine aminotransferase and mercaptopyruvate sulfurtransferase to hydrogen sulfide production in peripheral neurons

R Miyamoto, K Otsuguro… - Journal of …, 2014 - Wiley Online Library
Hydrogen sulfide (H2S) is a gaseous neuromodulator produced from L‐cysteine. H2S is
generated by three distinct enzymatic pathways mediated by cystathionine γ‐lyase (CSE) …

Oxygen glucose deprivation-induced astrocyte dysfunction provokes neuronal death through oxidative stress

E Gouix, A Buisson, A Nieoullon… - Pharmacological …, 2014 - Elsevier
Understanding the role of astrocytes in stroke is assuming increasing prominence, not only
as an important component on its own within the neurovascular unit, but also because …

[HTML][HTML] Role of N-acetylcysteine in rifampicin-induced hepatic injury of young rats

SV Rana, S Attri, K Vaiphei, R Pal, A Attri… - World Journal of …, 2006 - ncbi.nlm.nih.gov
AIM: To study the role of N-acetylcysteine (NAC) as a protective agent in rifampicin (RMP)-
induced oxidative hepatic injury of young rats. METHODS: Hepatic injury was produced by …

[HTML][HTML] Regulation of Glutathione in Health and Disease with Special Emphasis on Chronic Alcoholism and Hyperglycaemia Mediated Liver Injury: A Brief …

S Mathan Kumar, A Dey - Springer Science Reviews, 2014 - Springer
Glutathione (GSH) plays a major role in the cell due to its antioxidant properties. The
transcription factor Nrf2 plays an important role in the synthesis of GSH in the cell. Increased …

Treatment with aged garlic extract protects against bromobenzene toxicity to precision cut rat liver slices

BH Wang, KA Zuzel, K Rahman, D Billington - Toxicology, 1999 - Elsevier
Precision-cut liver slices from phenobarbital-induced rats were incubated for 6 h with the
model hepatotoxin bromobenzene (BB) at a final concentration of 1 mM. Severe toxicity was …

Rhodamine–propargylic esters for detection of mitochondrial hydrogen sulfide in living cells

X Chen, S Wu, J Han, S Han - Bioorganic & medicinal chemistry letters, 2013 - Elsevier
Rhodamine–propargylic esters for detection of mitochondrial hydrogen sulfide in living cells -
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Effect of glucose-cysteine adduct as a cysteine prodrug in rats

WB Yao, T Abe, Y Kurozumi, K Yukihiro, M Tomozawa… - Amino Acids, 1997 - Springer
Effect of intraperitoneal administration (5 mmol/kg of body weight) of glucose-cysteine
adduct (glc-cys) as a cysteine prodrug in rat tissues was studied. Cysteine levels in liver and …

Mitochondrial metabolism

S Rose, SC Bennuri - The Therapeutic Use of N-Acetylcysteine (NAC) in …, 2019 - Springer
Best known for their role in generating adenosine triphosphate (ATP) through oxidative
phosphorylation, mitochondria are responsible for a wide variety of vital cellular processes …