The renin-angiotensin system (RAS) is a key player in the control of the cardiovascular
system and hydroelectrolyte balance, with an influence on organs and functions throughout …

Cell proliferation is orchestrated through diverse proteins related to calcium (Ca 2+)
signaling inside the cell. Cellular Ca 2+ influx that occurs first by various mechanisms at the …

Santos Cardiovascular Actions of Angiotensin-(1–7) 1139 in caveolin 3 expression and a
decrease in heat shock protein 90. 28 These 2 alterations may lead to a decrease in eNOS …

The Mas-related G protein–coupled receptors (Mrgprs or Mas-related genes) comprise a
subfamily of receptors named after the first discovered member, Mas. For most Mrgprs …

The mineralocorticoid hormone aldosterone (Aldo) has been intensively studied for its ability
to influence both the physiology and pathophysiology of the cardiovascular system. Indeed …

Cardiovascular disease is the major cause of mortality and disability, with hypertension
being the most prevalent risk factor. Excessive activation of the renin-angiotensin system …

Background Cardiac hypertrophy and heart failure are characterized by increased late
sodium current and abnormal Ca2+ handling. Ranolazine, a selective inhibitor of the late …

Congestive heart failure (CHF) is often associated with impaired kidney function. Over-
activation of the renin–angiotensin–aldosterone system (RAAS) contributes to avid …

Hyper-aldosteronism is associated with myocardial dysfunction including induction of
cardiac fibrosis and maladaptive hypertrophy. Mechanisms of these cardiotoxicities are not …

Overstimulation of the renin-angiotensin system (RAS) has been implicated in the
pathogenesis of various cardiovascular diseases. Alamandine is a peptide newly identified …