Apathy and disinhibition are common and highly distressing neuropsychiatric symptoms
associated with negative outcomes in persons with dementia. This paper is a critical review …

The development of in vivo biomarkers of Alzheimer's disease (AD) has advanced the
diagnosis of AD from a clinical syndrome to a biological construct. The preclinical stage of …

Introduction: Simple markers are required to recognize older adults at higher risk for
neurodegenerative disease. Mild behavioural impairment (MBI) and plasma β-amyloid (Aβ) …

Classical laboratory strains show limited genetic diversity and do not harness natural
genetic variation. Mouse models relevant to Alzheimer's disease (AD) have largely been …

ABSTRACTNeuropsychiatric syndromes and symptoms play increasingly important roles in
research diagnostic criteria for neurodegenerative disorders. Diagnostic criteria were …

To identify knowledge gaps regarding new‐onset agitation and impulsivity prior to onset of
cognitive impairment or dementia the International Society to Advance Alzheimer's …

In clinical practice, the admission of patients with late-onset psychological and behavioural
symptoms is frequent, regardless of the presence or absence of cognitive decline. These …

Objective Alzheimer's disease (AD) is often associated with neuropsychiatric symptoms,
including agitation and aggressive behavior. These symptoms increase with disease …

The endocannabinoid system has been a target of interest for agitation in Alzheimer disease
(AD) because of potential behavioral effects and its potential impact on mechanisms …

Importance Previous genome-wide association studies of common variants identified
associations for Alzheimer disease (AD) loci evident only among individuals with …