Inwardly rectifying K+ (Kir) channels allow K+ to move more easily into rather than out of the
cell. They have diverse physiological functions depending on their type and their location …

Since 1929, when it was discovered that ATP is a substrate for muscle contraction, the
knowledge about this purine nucleotide has been greatly expanded. Many aspects of cell …

A subset of neurons in the brain, known as 'glucose-excited'neurons, depolarize and
increase their firing rate in response to increases in extracellular glucose. Similar to insulin …

The hypothalamus regulates many aspects of energy homeostasis, adjusting both the drive
to eat and the expenditure of energy in response to a wide range of nutritional and other …

Molecular Biology of Adenosine Triphosphate-Sensitive Potassium Channels* | Endocrine
Reviews | Oxford Academic Skip to Main Content Advertisement Oxford Academic Journals …

Over recent years, it has become clear that mitochondria play a central role in many key
aspects of animal physiology and pathophysiology. Their central and ubiquitous task is …

ATP-sensitive potassium (KATP) channels are present in many tissues, including pancreatic
islet cells, heart, skeletal muscle, vascular smooth muscle, and brain, in which they couple …

Leptin, the protein encoded by the obese (ob) gene, is secreted from adipose tissue and is
thought to act in the central nervous system to regulate food intake and body weight,. It has …

Glucose-responsive (GR) neurons in the hypothalamus are thought to be critical in glucose
homeostasis, but it is not known how they function in this context. Kir6. 2 is the pore-forming …

The importance of neuropeptides in the hypothalamus has been experimentally established.
Due to difficulties in assessing function in vivo, the roles of the fast-acting neurotransmitters …