Surgical resection represents the standard of care in diffuse glioma, and more extensive
tumour resection appears to be associated with favourable outcome. Up to now, terminology …

Simple Summary Diffuse low-grade gliomas (LGG) are relatively uncommon primary brain
cancers. In recent years, the molecular, diagnostic, and therapeutic approaches have …

Background Supratotal resection is advocated in lower-grade gliomas (LGGs) based on
theoretical advantages but with limited verification of functional risk and data on oncological …

Tissue microarrays (TMAs) are commonly used for the rapid analysis of large numbers of
tissue samples, often in morphological assessments but increasingly in spectroscopic …

Background PET with radiolabeled amino acids is used in the preoperative evaluation of
patients with glial neoplasms. This study aimed to assess the role of [11C] methionine (MET) …

Diffuse low-grade gliomas (DLGGs) are heterogeneous and poorly circumscribed
neoplasms with isolated tumor cells that extend beyond the margins of the lesion depicted …

Background With refinements in diagnosis and therapy of gliomas, the importance of
survival time as the sole outcome parameter has decreased, and patient-centered outcome …

Methylcytosine (m5C) methylation is present in almost all types of RNA as an essential
epigenetic modification. It is dynamically modulated by its associated enzymes, including …

OBJECTIVE Noninvasive brain mapping with functional MRI (fMRI) and mapping with direct
electrical stimulation (DES) are important tools in glioma surgery, but the evidence is …

Background The incidence and biology of IDH1/2 mutations in pediatric gliomas are unclear.
Notably, current treatment approaches by pediatric and adult providers vary significantly. We …