The glycocalyx of the endothelium is an intravascular compartment that creates a barrier
between circulating blood and the vessel wall. The glycocalyx is suggested to play an …

Diabetic kidney disease (DKD) remains a leading cause of new-onset end-stage renal
disease (ESRD), and yet, at present, the treatment is still very limited. A better understanding …

The size of nanoparticles plays a key role in utilizing enhanced permeability and retention
(EPR) effect of tumor, where large-sized nanoparticles possess good retention but poor …

Although progress has been indeed made by nanomedicines, their efficacies for cancer
treatment remain low, consequently leading to failures in translation to clinic. To improve the …

Pathophysiology of proteinuria. Proteinuria is consequence of two mechanisms: the
abnormal transglomerular passage of proteins due to increased permeability of glomerular …

Appreciation of the glomerular microcirculation as a specialized microcirculatory bed, rather
than as an entirely separate entity, affords important insights into both glomerular and …

Proteinuria is the hallmark of diabetic kidney disease (DKD) and is an independent risk
factor for both renal disease progression, and cardiovascular disease. Although the …

Microalbuminuria is an important risk factor for cardiovascular disease and progressive
renal impairment. This holds true in the general population and particularly in those with …

Glycocalyx, composed of glycoproteins including proteoglycans, coats the luminal surface of
the glomerular capillaries. Human heparanase degrades heparan sulphate …

Carl Erik Mogensen Medical Department M, Diabetes and Endocrinology, Aarhus
Kommunehospital, Aarhus University Hospital, Aarhus, Denmark (Modified from …