Pathogenesis and virulence of Candida albicans

JP Lopes, MS Lionakis - Virulence, 2022 - Taylor & Francis
Candida albicans is a commensal yeast fungus of the human oral, gastrointestinal, and
genital mucosal surfaces, and skin. Antibiotic-induced dysbiosis, iatrogenic …

Serum albumin: a multifaced enzyme

G De Simone, A di Masi, P Ascenzi - International Journal of Molecular …, 2021 - mdpi.com
Human serum albumin (HSA) is the most abundant protein in plasma, contributing actively to
oncotic pressure maintenance and fluid distribution between body compartments. HSA acts …

Vaginal Epithelial Cell Membrane-Based Phototherapeutic Decoy Confers a “Three-in-One” Strategy to Treat against Intravaginal Infection of Candida albicans

Y Lin, Q Yin, D Tian, X Yang, S Liu, X Sun, Q Chen… - ACS …, 2023 - ACS Publications
Phototherapy is an effective strategy to control Candida albicans (C. albicans) infection
without raising the concern of drug resistance. Despite its effectiveness, a higher dose of …

Nanobody-mediated neutralization of candidalysin prevents epithelial damage and inflammatory responses that drive vulvovaginal candidiasis pathogenesis

M Valentine, P Rudolph, A Dietschmann, A Tsavou… - MBio, 2024 - Am Soc Microbiol
Candida albicans can cause mucosal infections in humans. This includes oropharyngeal
candidiasis, which is commonly observed in human immunodeficiency virus infected …

Human serum albumin: From molecular aspects to biotechnological applications

A di Masi - International Journal of Molecular Sciences, 2023 - mdpi.com
Human serum albumin (HSA), the most abundant protein in plasma, is a monomeric
multidomain macromolecule that represents the main determinant of plasma oncotic …

Opportunistic yeast pathogen Candida spp.: Secreted and membrane-bound virulence factors

SJ Lim, MS Mohamad Ali, S Sabri… - Medical …, 2021 - academic.oup.com
Candidiasis is a fungal infection caused by Candida spp. especially Candida albicans, C.
glabrata, C. parapsilosis and C. tropicalis. Although the medicinal therapeutic strategies …

Serum albumin and nucleic acids biodistribution: From molecular aspects to biotechnological applications

GM Vita, G De Simone, E De Marinis, C Nervi… - IUBMB …, 2022 - Wiley Online Library
Serum albumin (SA) is the most abundant protein in plasma and represents the main carrier
of endogenous and exogenous compounds. Several evidence supports the notion that SA …

Sulfated glycosaminoglycans are host epithelial cell targets of the Candida albicans toxin candidalysin

J Lin, J Miao, KG Schaefer, CM Russell, RJ Pyron… - Nature …, 2024 - nature.com
Candidalysin, a cytolytic peptide produced by the fungal pathogen Candida albicans, is a
key virulence factor. However, its host cell targets remain elusive. Here we performed a …

Streptolysin O accelerates the conversion of plasminogen to plasmin

D Tang, H Khakzad, E Hjortswang, L Malmström… - Nature …, 2024 - nature.com
Abstract Group A Streptococcus (GAS) is a human-specific bacterial pathogen that can
exploit the plasminogen-plasmin fibrinolysis system to dismantle blood clots and facilitate its …

Functional analysis of the Candida albicans ECE1 Promoter

E Garbe, N Thielemann, S Hohner, A Kumar… - Microbiology …, 2023 - Am Soc Microbiol
The formation of hyphae is a key virulence attribute of Candida albicans as they are required
for adhesion to and invasion of host cells, and ultimately deep-tissue dissemination. Hyphae …