Alzheimer's disease (AD) is the most common neurodegenerative disease characterized by
cognitive impairment with few therapeutic options. Despite many failures in developing AD …

Mice transgenic for human mutant P301S tau are widely used as models for human
tauopathies. They develop neurodegeneration and abundant filamentous inclusions made …

Neurodegenerative diseases encompass a heterogeneous group of disorders that afflict
millions of people worldwide. Characteristic protein aggregates are histopathological …

A form of dementia distinct from healthy cognitive aging, Alzheimer's disease (AD) is a
complex multi-stage disease that currently afflicts over 50 million people worldwide …

The P301L mutation in tau protein is a prevalent pathogenic mutation associated with
neurodegenerative frontotemporal dementia, FTD. The mechanism by which P301L triggers …

Tau protein aggregation is associated with posttranslational modifications (PTMs) in 75% of
all dementia cases. The distribution of tau pathology and the presence of specific tau …

Background Alzheimer's disease (AD) is a widespread neurodegenerative disorder with a
significant global impact, affecting approximately 50 million individuals, and projections …

A prevailing hypothesis is that neurofibrillary tangles play a causal role in driving cognitive
decline in Alzheimer's disease (AD) because tangles correlate anatomically with areas that …

Repetitive mild traumatic brain injury (rmTBI, eg, sports concussions) may be associated
with both acute and chronic symptoms and neurological changes. Despite the common …

Mice transgenic for human P301S tau protein exhibit many characteristics of the human
tauopathies, including the formation of abundant hyperphoshorylated tau filaments, the …