Simple Summary Cancers have regions of low oxygen concentration where hypoxia-related
signaling pathways are activated. The hypoxic tumor microenvironment has been widely …

Idiopathic pulmonary fibrosis (IPF) is a chronic and progressive lung disease characterized
by excessive deposition of fibrotic connective tissue in the lungs. Emerging evidence …

Pulmonary fibrosis develops as a consequence of failed regeneration after injury. Analyzing
mechanisms of regeneration and fibrogenesis directly in human tissue has been hampered …

Background Idiopathic pulmonary fibrosis (IPF) is a heterogeneous disease that is
pathologically characterized by areas of normal-appearing lung parenchyma, active fibrosis …

The human 2-oxoglutarate (2OG)-and Fe (II)-dependent oxygenases factor inhibiting
hypoxia-inducible factor-α (FIH) and HIF-α prolyl residue hydroxylases 1–3 (PHD1–3) …

Dysregulated extracellular matrix is the hallmark of fibrosis, and it has a profound impact on
kidney function in disease. Furthermore, perturbation of matrix homeostasis is a feature of …

Fibrosis: How collagen becomes ‘stiff’ | eLife Skip to Content eLife logo eLife home page Menu
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A defining pathological feature of human lung fibrosis is localized tissue heterogeneity,
which challenges the interpretation of transcriptomic studies that typically lose spatial …

The factors that determine fibrosis progression or normal tissue repair are largely unknown.
We previously demonstrated that autophagy inhibition-mediated epithelial–mesenchymal …

Idiopathic pulmonary fibrosis (IPF) is a chronic progressive fibrotic disease of the lung with
poor prognosis. Fibrosis results from remodeling of the interstitial tissue. A wide range of …