The red edge: bilin-binding photoreceptors as optogenetic tools and fluorescence reporters

K Tang, HM Beyer, MD Zurbriggen… - Chemical …, 2021 - ACS Publications
This review adds the bilin-binding phytochromes to the Chemical Reviews thematic issue
“Optogenetics and Photopharmacology”. The work is structured into two parts. We first …

Red light optogenetics in neuroscience

K Lehtinen, MS Nokia, H Takala - Frontiers in Cellular Neuroscience, 2022 - frontiersin.org
Optogenetics, a field concentrating on controlling cellular functions by means of light-
activated proteins, has shown tremendous potential in neuroscience. It possesses superior …

Construction of Pt/Pt-Au doped chiral nanostructures using arginine and porphyrin assemblies as templates for enantioselective photocatalysis

X Yue, L Xu, H Lin, C Xu, S Li - Science Bulletin, 2023 - Elsevier
Chiral nanomaterials with different functions have been widely developed, but the deep
understanding of the structural effects of nanocatalysts on enantioselective photocatalytic …

[HTML][HTML] Cyanobacteriochromes from Gloeobacterales provide new insight into the diversification of cyanobacterial photoreceptors

NC Rockwell, JC Lagarias - Journal of Molecular Biology, 2024 - Elsevier
The phytochrome superfamily comprises three groups of photoreceptors sharing a
conserved GAF (cGMP-specific phosphodiesterases, cyanobacterial adenylate cyclases …

Frontiers in multiscale modeling of photoreceptor proteins

M Mroginski, S Adam, GS Amoyal… - Photochemistry and …, 2021 - Wiley Online Library
This perspective article highlights the challenges in the theoretical description of
photoreceptor proteins using multiscale modeling, as discussed at the CECAM workshop in …

A far-red cyanobacteriochrome lineage specific for verdins

MV Moreno, NC Rockwell, M Mora… - Proceedings of the …, 2020 - National Acad Sciences
Cyanobacteriochromes (CBCRs) are photoswitchable linear tetrapyrrole (bilin)-based light
sensors in the phytochrome superfamily with a broad spectral range from the near UV …

On the Role of a Conserved Tryptophan in the Chromophore Pocket of Cyanobacteriochrome

M Blain-Hartung, GJ von Sass, J Plaickner… - Journal of Molecular …, 2024 - Elsevier
The cyanobacteriochrome Slr1393 can be photoconverted between a red (Pr) and green
absorbing form (Pg). The recently determined crystal structures of both states suggest a …

Fine spectral tuning of a flavin-binding fluorescent protein for multicolor imaging

A Nikolaev, A Yudenko, A Smolentseva… - Journal of Biological …, 2023 - ASBMB
Flavin-binding fluorescent proteins are promising genetically encoded tags for microscopy.
However, spectral properties of their chromophores (riboflavin, flavin mononucleotide, and …

Transient 2D IR spectroscopy and multiscale simulations reveal vibrational couplings in the Cyanobacteriochrome Slr1393-g3

D Buhrke, Y Lahav, A Rao, J Ruf… - Journal of the …, 2023 - ACS Publications
Cyanobacteriochromes are bistable photoreceptor proteins with desirable photochemical
properties for biotechnological applications, such as optogenetics or fluorescence …

Crystal structure of a far-red–sensing cyanobacteriochrome reveals an atypical bilin conformation and spectral tuning mechanism

S Bandara, NC Rockwell, X Zeng… - Proceedings of the …, 2021 - National Acad Sciences
Cyanobacteriochromes (CBCRs) are small, linear tetrapyrrole (bilin)-binding photoreceptors
in the phytochrome superfamily that regulate diverse light-mediated adaptive processes in …