Cellular responses to environmental cues involve the mobilization of GTPases, protein
kinases and phosphoprotein phosphatases. The spatial organization of these signalling …

Multiprotein signalling networks create focal points of enzyme activity that disseminate the
intracellular action of many hormones and neurotransmitters. Accordingly, the spatio …

Over the last two decades, a new and unifying concept of cellular organization has emerged
in which modular protein-protein interactions provide an underlying framework through …

K+ channels play a crucial role in regulating the excitability of neurons. Many K+ channels
are, in turn, regulated by neurotransmitters. One of the first neurotransmitter-regulated …

Regulatory enzymes often have different roles in distinct subcellular compartments. Yet,
most drugs indiscriminately saturate the cell. Thus, subcellular drug-delivery holds promise …

KCNQ (KV7) potassium channels underlie subthreshold M-currents that stabilize the
neuronal resting potential and prevent repetitive firing of action potentials. Here, antibodies …

Neuronal Kv7 channels underlie a voltage-gated non-inactivating potassium current known
as the M-current. Due to its particular characteristics, Kv7 channels show pronounced …

This review addresses the localized regulation of voltage-gated ion channels by
phosphorylation. Comprehensive data on channel regulation by associated protein kinases …

Phosphatidylinositol 4, 5-bisphosphate is a signaling phospholipid of the plasma membrane
that has a dynamically changing concentration. In addition to being the precursor of inositol …

Seizures are the most common neurological manifestation in the newborn period, with an
estimated incidence of 1.8–3.5 per 1000 live births. Prolonged or intractable seizures have a …