HPV-associated oropharyngeal cancer: epidemiology, molecular biology and clinical management
Abstract Human papillomavirus (HPV)-positive (HPV+) oropharyngeal squamous cell
carcinoma (OPSCC) has one of the most rapidly increasing incidences of any cancer in high …
carcinoma (OPSCC) has one of the most rapidly increasing incidences of any cancer in high …
B cell function in the tumor microenvironment
SM Downs-Canner, J Meier, BG Vincent… - Annual review of …, 2022 - annualreviews.org
The tumor microenvironment (TME) is a heterogeneous, complex organization composed of
tumor, stroma, and endothelial cells that is characterized by cross talk between tumor and …
tumor, stroma, and endothelial cells that is characterized by cross talk between tumor and …
Improving head and neck cancer therapies by immunomodulation of the tumour microenvironment
AT Ruffin, H Li, L Vujanovic, DP Zandberg… - Nature Reviews …, 2023 - nature.com
Targeted immunotherapy has improved patient survival in head and neck squamous cell
carcinoma (HNSCC), but less than 20% of patients produce a durable response to these …
carcinoma (HNSCC), but less than 20% of patients produce a durable response to these …
B cell signatures and tertiary lymphoid structures contribute to outcome in head and neck squamous cell carcinoma
Current immunotherapy paradigms aim to reinvigorate CD8+ T cells, but the contribution of
humoral immunity to antitumor immunity remains understudied. Here, we demonstrate that in …
humoral immunity to antitumor immunity remains understudied. Here, we demonstrate that in …
Immune landscape of viral-and carcinogen-driven head and neck cancer
Head and neck squamous cell carcinoma (HNSCC) arises through exposure to
environmental carcinogens or malignant transformation by human papillomavirus (HPV) …
environmental carcinogens or malignant transformation by human papillomavirus (HPV) …
Assessing tumor-infiltrating lymphocytes in solid tumors: a practical review for pathologists and proposal for a standardized method from the International Immuno …
S Hendry, R Salgado, T Gevaert… - Advances in anatomic …, 2017 - journals.lww.com
Assessment of the immune response to tumors is growing in importance as the prognostic
implications of this response are increasingly recognized, and as immunotherapies are …
implications of this response are increasingly recognized, and as immunotherapies are …
Head and neck squamous cell carcinoma: Genomics and emerging biomarkers for immunomodulatory cancer treatments
Head and neck squamous cell carcinoma (HNSCC) comprises a heterogeneous group of
tumors that arise from the squamous epithelium of the oral cavity, oropharynx, larynx and …
tumors that arise from the squamous epithelium of the oral cavity, oropharynx, larynx and …
Pan-cancer deconvolution of tumour composition using DNA methylation
The nature and extent of immune cell infiltration into solid tumours are key determinants of
therapeutic response. Here, using a DNA methylation-based approach to tumour cell …
therapeutic response. Here, using a DNA methylation-based approach to tumour cell …
Tumor immunity and immunotherapy for HPV-related cancers
Human papillomavirus (HPV) infection drives tumorigenesis in the majority of cervical,
oropharyngeal, anal, and vulvar cancers. Genetic and epidemiologic evidence has …
oropharyngeal, anal, and vulvar cancers. Genetic and epidemiologic evidence has …
Single-cell transcriptomic analysis of tissue-resident memory T cells in human lung cancer
High numbers of tissue-resident memory T (TRM) cells are associated with better clinical
outcomes in cancer patients. However, the molecular characteristics that drive their efficient …
outcomes in cancer patients. However, the molecular characteristics that drive their efficient …