[HTML][HTML] SARS-CoV-2 vaccines based on the spike glycoprotein and implications of new viral variants

D Martínez-Flores, J Zepeda-Cervantes… - Frontiers in …, 2021 - frontiersin.org
Coronavirus 19 Disease (COVID-19) originating in the province of Wuhan, China in 2019, is
caused by the severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2), whose …

[HTML][HTML] Structural characterization of SARS-CoV-2: where we are, and where we need to be

G Mariano, RJ Farthing, SLM Lale-Farjat… - Frontiers in molecular …, 2020 - frontiersin.org
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has rapidly spread in
humans in almost every country, causing the disease COVID-19. Since the start of the …

[HTML][HTML] A comprehensive review on the global efforts on vaccines and repurposed drugs for combating COVID-19

ND Kushwaha, J Mohan, B Kushwaha, T Ghazi… - European Journal of …, 2023 - Elsevier
The recently discovered coronavirus, known as SARS-CoV-2, is a highly contagious and
potentially lethal viral infection that was declared a pandemic by the World Health …

[HTML][HTML] Membrane hemifusion: crossing a chasm in two leaps

LV Chernomordik, MM Kozlov - Cell, 2005 - cell.com
During membrane fusion, the outer leaflets of the two membranes merge first, whereas the
distal membrane leaflets remain separate until the opening of a fusion pore. This …

Antiviral antibody responses: the two extremes of a wide spectrum

L Hangartner, RM Zinkernagel… - Nature Reviews …, 2006 - nature.com
Viruses elicit a diverse spectrum of antiviral antibody responses. In this review, we discuss
two widely used experimental model systems for viral infections—non-cytopathic …

Flavivirus membrane fusion

K Stiasny, FX Heinz - Journal of general virology, 2006 - microbiologyresearch.org
Flavivirus membrane fusion is mediated by a class II viral fusion protein, the major envelope
protein E, and the fusion process is extremely fast and efficient. Understanding of the …

Cryptic properties of a cluster of dominant flavivirus cross-reactive antigenic sites

K Stiasny, S Kiermayr, H Holzmann, FX Heinz - Journal of virology, 2006 - Am Soc Microbiol
ABSTRACT A number of flaviviruses are important human pathogens, including yellow
fever, dengue, West Nile, Japanese encephalitis, and tick-borne encephalitis (TBE) viruses …

Characterization of fusion determinants points to the involvement of three discrete regions of both E1 and E2 glycoproteins in the membrane fusion process of hepatitis …

D Lavillette, EI Pécheur, P Donot, J Fresquet… - Journal of …, 2007 - Am Soc Microbiol
Infection of eukaryotic cells by enveloped viruses requires the merging of viral and cellular
membranes. Highly specific viral surface glycoproteins, named fusion proteins, catalyze this …

Folding and stability of α-helical integral membrane proteins

KR MacKenzie - Chemical reviews, 2006 - ACS Publications
Integral membrane proteins are embedded in a watersolvated lipid bilayer that presents
contrasting features in an anisotropic, chemically heterogeneous environment. A …

[HTML][HTML] The role of histidine residues in low-pH-mediated viral membrane fusion

T Kampmann, DS Mueller, AE Mark, PR Young, B Kobe - Structure, 2006 - cell.com
A central event in the invasion of a host cell by an enveloped virus is the fusion of viral and
cell membranes. For many viruses, membrane fusion is driven by specific viral surface …