Lipid peroxidation: production, metabolism, and signaling mechanisms of malondialdehyde and 4‐hydroxy‐2‐nonenal

A Ayala, MF Muñoz, S Argüelles - Oxidative medicine and …, 2014 - Wiley Online Library
Lipid peroxidation can be described generally as a process under which oxidants such as
free radicals attack lipids containing carbon‐carbon double bond (s), especially …

[HTML][HTML] Mitochondrial dysfunction and oxidative stress in aging and cancer

AV Kudryavtseva, GS Krasnov, AA Dmitriev… - Oncotarget, 2016 - ncbi.nlm.nih.gov
Aging and cancer are the most important issues to research. The population in the world is
growing older, and the incidence of cancer increases with age. There is no doubt about the …

The relevance of pathophysiological alterations in redox signaling of 4-hydroxynonenal for pharmacological therapies of major stress-associated diseases

M Jaganjac, L Milkovic, A Gegotek, M Cindric… - Free Radical Biology …, 2020 - Elsevier
Modern analytical methods combined with the modern concepts of redox signaling revealed
4-hydroxy-2-nonenal (4-HNE) as particular growth regulating factor involved in redox …

Sulforaphane protects the heart from doxorubicin-induced toxicity

P Singh, R Sharma, K McElhanon, CD Allen… - Free Radical Biology …, 2015 - Elsevier
Cardiotoxicity is one of the major side effects encountered during cancer chemotherapy with
doxorubicin (DOX) and other anthracyclines. Previous studies have shown that oxidative …

[HTML][HTML] Antioxidant modulation of sirtuin 3 during acute inflammatory pain: The ROS control

S Ilari, LA Giancotti, F Lauro, C Dagostino… - Pharmacological …, 2020 - Elsevier
Oxidative stress induced post-translational protein modifications are associated with the
development of inflammatory hypersensitivities. At least 90% of cellular reactive oxygen …

Overview on major lipid peroxidation bioactive factor 4-hydroxynonenal as pluripotent growth-regulating factor

L Milkovic, A Cipak Gasparovic… - Free Radical …, 2015 - Taylor & Francis
The reactive aldehyde 4-hydroxynonenal (HNE) is major bioactive marker of lipid
peroxidation generated under oxidative stress from polyunsaturated fatty acids. Biomedical …

Mitochondrial dysfunction in the APP/PSEN1 mouse model of Alzheimer's disease and a novel protective role for ascorbate

S Dixit, JP Fessel, FE Harrison - Free Radical Biology and Medicine, 2017 - Elsevier
Mitochondrial dysfunction is elevated in very early stages of Alzheimer's disease and
exacerbates oxidative stress, which contributes to disease pathology. Mitochondria were …

Microbiological and toxicological hazards in sewage treatment plant bioaerosol and dust

J Szulc, M Okrasa, K Majchrzycka, M Sulyok, A Nowak… - Toxins, 2021 - mdpi.com
Despite the awareness that work in the sewage treatment plant is associated with biological
hazards, they have not been fully recognised so far. The research aims to comprehensively …

Neuroprotective Mechanism of Lycium barbarum Polysaccharides against Hippocampal-Dependent Spatial Memory Deficits in a Rat Model of Obstructive Sleep …

CS Lam, GL Tipoe, KF So, ML Fung - PLoS One, 2015 - journals.plos.org
Chronic intermittent hypoxia (CIH) is a hallmark of obstructive sleep apnea (OSA), which
induces hippocampal injuries mediated by oxidative stress. This study aims to examine the …

[HTML][HTML] Alda-1 reduces cerebral ischemia/reperfusion injury in rat through clearance of reactive aldehydes

SH Fu, HF Zhang, ZB Yang, TB Li, B Liu, Z Lou… - Naunyn-Schmiedeberg's …, 2014 - Springer
Many studies demonstrate that accumulation of reactive aldehydes plays an important role
in cellular oxidative injury and aldehyde dehydrogenase 2 (ALDH2)-mediated detoxification …