Expanding antibiotic, vaccine, and diagnostics development and access to tackle antimicrobial resistance

R Laxminarayan, I Impalli, R Rangarajan, J Cohn… - The Lancet, 2024 - thelancet.com
The increasing number of bacterial infections globally that do not respond to any available
antibiotics indicates a need to invest in—and ensure access to—new antibiotics, vaccines …

CRISPR Diagnostics for WHO High-Priority Sexually Transmitted Infections

I Gul, MA Raheem, L Lian, AM Karim, BB Heyat… - TrAC Trends in …, 2024 - Elsevier
Sexually transmitted infections (STIs) pose a global health threat. Most of these infections
are curable if detected in a timely and accurate manner. In 2022, the World Health …

Recent advances in centrifugal microfluidics for point-of-care testing

H Yuan, Z Miao, C Wan, J Wang, J Liu, Y Li, Y Xiao… - Lab on a Chip, 2025 - pubs.rsc.org
Point-of-care testing (POCT) holds significant importance in the field of infectious disease
prevention and control, as well as personalized precision medicine. The emerging …

Role of HIV self-testing in strengthening HIV prevention services

Y Zhang, CC Johnson, JJ Ong - The Lancet HIV, 2024 - thelancet.com
HIV self-testing, which has been increasingly available since 2016, can substantially
enhance the uptake of HIV testing, especially for key populations. Clinical trials have …

Development of a Novel Fluorescent-Based Lateral Flow Assay for the Detection of Neisseria gonorrhoeae at the Point of Care

B Gleeson, J Piton, L Mazzola, S McHugh… - Sexually Transmitted …, 2024 - journals.lww.com
Background Neisseria gonorrhoeae (NG) has acquired significant resistance, primarily due
to extensive and unwarranted antibiotic utilization over several decades. This resistance has …

Preliminary clinical performance of a Cas13a-based lateral flow assay for detecting Neisseria gonorrhoeae in urine specimens

LT Allan-Blitz, G Adams, G Sanders, P Shah… - mSphere, 2024 - journals.asm.org
Nucleic acid amplification testing (NAAT) for N. gonorrhoeae is unavailable in resource-
limited settings. We previously developed a CRISPR-based lateral flow assay for detecting …

Tackling antimicrobial resistance: recognising the proposed five blind spots can accelerate progress

M Pai, S Gandra, P Thapa, S Carmona - The Lancet Microbe, 2024 - thelancet.com
Antimicrobial resistance (AMR), a huge global health threat, will be back in the spotlight
when the UN will conduct a second high-level meeting on AMR in September, 2024. Ahead …

A lateral flow assay for Neisseria gonorrhoeae: a step forward for an inexpensive biomarker-based diagnosis of N gonorrhoeae at the point of care?

NP Pai, JAR Dillon - The Lancet, 2024 - thelancet.com
At least one million curable sexually transmitted infections (STIs) are acquired daily, and
their long-term consequences affect reproductive health, psychological health, neonatal …

[HTML][HTML] Clinical Performance of Cas13a-based Point-of-Care Lateral Flow Assay for Detecting Neisseria gonorrhoeae

LT Allan-Blitz, G Sanders, P Shah, G Adams… - medRxiv, 2024 - ncbi.nlm.nih.gov
Background Diagnosis of Neisseria (N.) gonorrhoeae is dependent on nucleic acid
amplification testing (NAAT), which is not available in resource-limited settings where the …

[HTML][HTML] Multi-repeat sequences identification using genome mining techniques for developing highly sensitive molecular diagnostic assay for the detection of …

C Shiluli, S Kamath, BN Kanoi, R Kimani… - Open Research …, 2024 - ncbi.nlm.nih.gov
Chlamydia trachomatis (C. trachomatis) is a common sexually transmitted infection (STI). In
2019, the World Health Organization reported about 131 million infections. The majority of …