In order to achieve coordinated growth and patterning during development, cells must
communicate with one another, sending and receiving signals that regulate their activities …

Hedgehog (Hh) is first described as a genetic mutation that has “spiked” phenotype in the
cuticles of Drosophila in later 1970s. Since then, Hh signaling has been implicated in …

The Wnt signaling pathway regulates cell proliferation, differentiation, migration, genetic
stability, and apoptosis in almost all tissues and organs. It plays a crucial role in the normal …

Since its first description in Drosophila by Drs Nusslein-Volhard and Wieschaus in 1980,
hedgehog (Hh) signaling has been implicated in regulation of cell differentiation …

Hedgehog can signal both at a short and long-range, and acts as a morphogen during
development in various systems. We studied the mechanisms of Hh release and spread …

The present study aimed to investigate the expression of long non‑coding HOX transcript
antisense RNA (lncRNA‑HOTAIR) in the serum of patients with lymph node metastasis of …

Hedgehog (Hh) as morphogen directs cell differentiation during development activating
various target genes in a concentration dependent manner. The mechanisms that permit …

The prognosis of hepatocellular carcinoma patients is usually poor, the size of tumors being
a limiting factor for surgical treatments. Present results suggest that the overexpression of …

The hedgehog (Hh) signaling protein has essential roles in the growth, development and
regulation of many vertebrate and invertebrate organs. The processes that make Hh and …

Abstract Wnts and Hedgehogs (Hh) are large, lipid-modified extracellular morphogens that
play key roles in embryonic development and stem cell proliferation of Metazoa. Both …