The T cell receptor (TCR) complex is a naturally occurring antigen sensor that detects,
amplifies and coordinates cellular immune responses to epitopes derived from cell surface …

T cells are a critical part of the adaptive immune system that are able to distinguish between
healthy and unhealthy cells. Upon recognition of protein fragments (peptides), activated T …

How the engagement of a T-cell receptor to antigenic peptide-loaded major
histocompatibility complex on antigen-presenting cells (APCs) initiates intracellular …

TCR-signaling strength generally correlates with peptide-MHC binding affinity; however,
exceptions exist. We find high-affinity, yet non-stimulatory, interactions occur with high …

TCR-pMHC interactions initiate adaptive immune responses, but the mechanism of how
such interactions under force induce T cell signaling is unclear. We show that force prolongs …

Metastasis is a complex, multistep process responsible for> 90% of cancer-related deaths. In
addition to genetic and external environmental factors, the physical interactions of cancer …

INTRODUCTION The adaptive immune system has evolved to mount different types of
responses that are matched to the type of invading pathogen. For CD4+ T cells, this is …

Ten years ago, we wrote a Review on lipid rafts and signalling in the launch issue of Nature
Reviews Molecular Cell Biology. At the time, this field was suffering from ambiguous …

Cadherins are the principal adhesion proteins at intercellular junctions and function as the
biochemical Velcro that binds cells together. Besides this mechanical function, cadherin …

Immunotherapy will significantly impact the standard of care in cancer treatment. Recent
advances in nanotechnology can improve the efficacy of cancer immunotherapy. However …