A 360 view of the inflammasome: Mechanisms of activation, cell death, and diseases
Inflammasomes are critical sentinels of the innate immune system that respond to threats to
the host through recognition of distinct molecules, known as pathogen-or damage …
the host through recognition of distinct molecules, known as pathogen-or damage …
The NLR gene family: from discovery to present day
The mammalian NLR gene family was first reported over 20 years ago, although several
genes that were later grouped into the family were already known at that time. Although it is …
genes that were later grouped into the family were already known at that time. Although it is …
Interaction between microbiota and immunity in health and disease
The interplay between the commensal microbiota and the mammalian immune system
development and function includes multifold interactions in homeostasis and disease. The …
development and function includes multifold interactions in homeostasis and disease. The …
Potential intestinal infection and faecal–oral transmission of SARS-CoV-2
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has spread to more than
200 countries and regions globally. SARS-CoV-2 is thought to spread mainly through …
200 countries and regions globally. SARS-CoV-2 is thought to spread mainly through …
Inflammasome activation and regulation: toward a better understanding of complex mechanisms
Inflammasomes are cytoplasmic multiprotein complexes comprising a sensor protein,
inflammatory caspases, and in some but not all cases an adapter protein connecting the two …
inflammatory caspases, and in some but not all cases an adapter protein connecting the two …
Role of the inflammasome in liver disease
M de Carvalho Ribeiro, G Szabo - Annual Review of Pathology …, 2022 - annualreviews.org
The involvement of inflammasomes in the proinflammatory response observed in chronic
liver diseases, such as alcohol-associated liver disease (ALD) and nonalcoholic fatty liver …
liver diseases, such as alcohol-associated liver disease (ALD) and nonalcoholic fatty liver …
Phase separation drives RNA virus-induced activation of the NLRP6 inflammasome
NLRP6 is important in host defense by inducing functional outcomes including
inflammasome activation and interferon production. Here, we show that NLRP6 undergoes …
inflammasome activation and interferon production. Here, we show that NLRP6 undergoes …
Emerging activators and regulators of inflammasomes and pyroptosis
The inflammasome is a cytosolic immune signaling complex that induces inflammation and
pyroptosis. Inflammasome complexes respond to a variety of pathogens, as well as danger …
pyroptosis. Inflammasome complexes respond to a variety of pathogens, as well as danger …
Inflammasomes: mechanism of assembly, regulation and signalling
Inflammasomes are multiprotein signalling platforms that control the inflammatory response
and coordinate antimicrobial host defences. They are assembled by pattern-recognition …
and coordinate antimicrobial host defences. They are assembled by pattern-recognition …
The microbiome and innate immunity
The intestinal microbiome is a signalling hub that integrates environmental inputs, such as
diet, with genetic and immune signals to affect the host's metabolism, immunity and …
diet, with genetic and immune signals to affect the host's metabolism, immunity and …