Fascin actin-bundling protein 1 (FSCN1) is a highly conserved actin-bundling protein that
cross links F-actin microfilaments into tight, parallel bundles. Elevated FSCN1 levels have …

Gliomas encompass highly invasive primary central nervous system (CNS) tumours of glial
cell origin with an often-poor clinical prognosis. Of all gliomas, glioblastoma is the most …

Glioblastoma (GBM) is the most common and devastating malignant brain tumor in adults.
The mortality rate is very high despite different treatments. New therapeutic targets are …

Abstract H3K27-altered Diffuse Midline Glioma (DMG) is a universally fatal paediatric
brainstem tumour. The prevalent driver mutation H3K27M creates a unique epigenetic …

Metastasis is the main cause of mortality in patients with cancer. Epithelial–mesenchymal
transition (EMT), a crucial process in cancer metastasis, is an established target for …

In solid tumors, hypoxia facilitates malignant progression of cancer cells by triggering
epithelial-mesenchymal transition (EMT) and cancer stemness. Fascin-1, an actin-bundling …

Glioblastoma (GB) is a cancerous brain tumor that originates from glial cells and leads to
thousands of deaths each year and a five-year survival of only 6.8%. Treatments for GB …

Background: Bladder cancer (BC) is a common cause of cancer-relevant deaths globally.
This study is designed to delve into expressions, biological functions and molecular …

Glioblastoma (GBM) is one of the most devastating cancers, with an approximate median
survival of only 16 months. Although some new insights into the fantastic heterogeneity of …

Rheumatoid arthritis (RA) is a chronic, multi-factorial disease characterized by Synovial
hyperplasia, chronic inflammation, and autoimmune reaction. Fascin1 overexpression has …