Forced expression of proneural transcription factors has been shown to direct neuronal
conversion of fibroblasts. Because neurons are postmitotic, conversion efficiencies are an …

An intriguing question in human embryonic stem cell (hESC) biology is whether these
pluripotent cells can give rise to stably expandable somatic stem cells, which are still …

Developing procedures for the derivation of human pluripotent stem cells (PSCs) gave rise
to novel pathways into regenerative medicine research. For many years, stem cells have …

Malformations of human cortical development (MCD) can cause severe disabilities. The lack
of human‐specific models hampers our understanding of the molecular underpinnings of the …

Alzheimer's disease (AD) is the most frequent cause of dementia. There is compelling
evidence that the proteolytic processing of the amyloid precursor protein (APP) and …

Induction of pluripotent stem cells from human fibroblasts has been achieved by the ectopic
expression of two different sets of four genes. However, the mechanism of the pluripotent …

Metachromatic leukodystrophy (MLD) is an inherited lysosomal storage disorder resulting
from a functional deficiency of arylsulfatase A (ARSA), an enzyme that catalyzes desulfation …

While the availability of pluripotent stem cells has opened new prospects for generating
neural donor cells for nervous system repair, their capability to integrate with adult brain …

High-efficiency genetic modification of human embryonic stem (hES) cells would enable
manipulation of gene activity, routine gene targeting, and development of new human …

In this study, we targeted Olig2, a basic helix-loop-helix transcription factor that plays an
important role in motoneuron and oligodendrocyte development, in human embryonic stem …