Accurate estimation of SNP-heritability from biobank-scale data irrespective of genetic architecture
SNP-heritability is a fundamental quantity in the study of complex traits. Recent studies have
shown that existing methods to estimate genome-wide SNP-heritability can yield biases …
shown that existing methods to estimate genome-wide SNP-heritability can yield biases …
Annotations capturing cell type-specific TF binding explain a large fraction of disease heritability
Regulatory variation plays a major role in complex disease and that cell type-specific
binding of transcription factors (TF) is critical to gene regulation. However, assessing the …
binding of transcription factors (TF) is critical to gene regulation. However, assessing the …