CD44, a non-kinase cell surface transmembrane glycoprotein, has been widely implicated
as a cancer stem cell (CSC) marker in several cancers. Cells overexpressing CD44 possess …

Epithelial-to-mesenchymal transition (EMT) mechanism is responsible for metastasis of
tumor cells and their spread to various organs and tissues of body, providing undesirable …

Doxorubicin (DOX) is a well-known chemotherapeutic agent extensively applied in the field
of cancer therapy. However, similar to other chemotherapeutic agents such as cisplatin …

Given the long-term ineffectiveness of current therapies and late-stage diagnoses, lung
cancer is a leading cause of malignant diseases. Tumor progression is influenced by cancer …

Cancer stem cells (CSCs), initially identified in leukemia in 1994, constitute a distinct subset
of tumor cells characterized by surface markers such as CD133, CD44, and ALDH. Their …

Neutrophils sense microbes and host inflammatory mediators, and traffic to sites of infection
where they direct a broad armamentarium of antimicrobial products against pathogens …

Epithelial mesenchymal transition (EMT) is a process comprising cellular and molecular
events which result in cells shifting from an epithelial to a mesenchymal phenotype …

Non-small cell lung cancer (NSCLC) is a leading cause of cancer death. Tumor progression
depends on interactions of cancer cells with the tumor microenvironment. Here, we find …

Autoimmune disease results from the immune response against self-antigens, while cancer
develops when the immune system does not respond to malignant cells. Thus, for years …

Simple Summary MMP-13 is an enzyme that can digest and disrupt the tissue structures
surrounding epithelial cells that line the surface of many internal organs, as well as the …