Neurons that synthesize and release 5-hydroxytryptamine (5-HT; serotonin) express a core
set of genes that establish and maintain this neurotransmitter phenotype and distinguish …

We take for granted the ability to fall asleep or to snap out of sleep into wakefulness, but
these changes in behavioral state require specific switching mechanisms in the brain that …

Offering up-to-date coverage of everything from historical and international perspectives to
basic science and today's clinical practice, Miller's Anesthesia, 10th Edition, remains the# 1 …

The dorsal raphe nucleus (DRN) is involved in organizing reward-related behaviours;
however, it remains unclear how genetically defined neurons in the DRN of a freely …

Switches between different behavioral states of the animal are associated with prominent
changes in global brain activity, between sleep and wakefulness or from inattentive to …

The dorsal raphe nucleus (DRN) in the midbrain is a key center for serotonin (5-
hydroxytryptamine; 5-HT)-expressing neurons. Serotonergic neurons in the DRN have been …

Serotonin's function in the brain is unclear. One challenge in testing the numerous
hypotheses about serotonin's function has been observing the activity of identified …

In the cerebral cortex, diverse types of neurons form intricate circuits and cooperate in time
for the processing and storage of information. Recent advances reveal a spatiotemporal …

Anxiety disorders are the most prevalent mental health conditions. Although they are less
visible than schizophrenia, depression, and bipolar disorder, they can be just as disabling …

Decreased serotonergic activity has been implicated in anxiety and major depression, and
antidepressants directly or indirectly increase the long-term activity of the serotonin system …