Xpert MTB/XDR for detection of pulmonary tuberculosis and resistance to isoniazid, fluoroquinolones, ethionamide, and amikacin
GR Davies, M Chaplin, M De Vos… - Cochrane Database …, 2022 - cochranelibrary.com
Background The World Health Organization (WHO) End TB Strategy stresses universal
access to drug susceptibility testing (DST). DST determines whether Mycobacterium …
access to drug susceptibility testing (DST). DST determines whether Mycobacterium …
Whole genome sequencing of Mycobacterium tuberculosis isolates and clinical outcomes of patients treated for multidrug-resistant tuberculosis in Tanzania
BZ Katale, PM Mbelele, NA Lema, S Campino… - BMC genomics, 2020 - Springer
Background Tuberculosis (TB), particularly multi-and or extensive drug resistant TB, is still a
global medical emergency. Whole genome sequencing (WGS) is a current alternative to the …
global medical emergency. Whole genome sequencing (WGS) is a current alternative to the …
Prevalence and extent of heteroresistance by next generation sequencing of multidrug-resistant tuberculosis
DJ Operario, AF Koeppel, SD Turner, Y Bao… - PLoS …, 2017 - journals.plos.org
Amplicon-based Next Generation Sequencing (NGS) is an emerging method for
Mycobacterium tuberculosis drug susceptibility testing (DST) but has not been well …
Mycobacterium tuberculosis drug susceptibility testing (DST) but has not been well …
Meta-narrative review of molecular methods for diagnosis and monitoring of multidrug-resistant tuberculosis treatment in adults
PM Mbelele, SY Mohamed, E Sauli… - The International …, 2018 - journals.lww.com
Early and accurate diagnosis and rigorous clinical and microbiological monitoring of
multidrug-resistant tuberculosis (MDR-TB) treatment can curb morbidity and mortality. While …
multidrug-resistant tuberculosis (MDR-TB) treatment can curb morbidity and mortality. While …
Linking minimum inhibitory concentrations to whole genome sequence-predicted drug resistance in Mycobacterium tuberculosis strains from Romania
Mycobacterium tuberculosis drug resistance poses a major threat to tuberculosis control.
Current phenotypic tests for drug susceptibility are time-consuming, technically complex …
Current phenotypic tests for drug susceptibility are time-consuming, technically complex …
Fluoroquinolones in drug-resistant tuberculosis: culture conversion and pharmacokinetic/pharmacodynamic target attainment to guide dose selection
MH Al-Shaer, WA Alghamdi, A Alsultan… - Antimicrobial agents …, 2019 - Am Soc Microbiol
Fluoroquinolones are group A drugs in tuberculosis guidelines. We aim to compare the
culture conversion between new-generation (levofloxacin and moxifloxacin) and old …
culture conversion between new-generation (levofloxacin and moxifloxacin) and old …
Underestimated pyrazinamide resistance may compromise outcomes of pyrazinamide containing regimens for treatment of drug susceptible and multi-drug-resistant …
SP Juma, A Maro, S Pholwat, SG Mpagama… - BMC infectious …, 2019 - Springer
Background Tuberculosis (TB) is the leading cause of death from an infectious disease and
the roll-out of rapid molecular diagnostics for rifampin resistance has resulted in a steady …
the roll-out of rapid molecular diagnostics for rifampin resistance has resulted in a steady …
[HTML][HTML] Simultaneous detection of multiple pathogens with the TaqMan Array Card
R Lappan, T Jirapanjawat, DA Williamson, S Lange… - MethodsX, 2022 - Elsevier
Quantitative polymerase chain reaction (qPCR) is a gold standard method for the detection
and quantification of pathogenic organisms. Standard qPCR is inexpensive, sensitive and …
and quantification of pathogenic organisms. Standard qPCR is inexpensive, sensitive and …
The malaria TaqMan array card includes 87 assays for Plasmodium falciparum drug resistance, Identification of species, and genotyping in a single reaction
Antimalarial drug resistance exacerbates the global disease burden and complicates
eradication efforts. To facilitate the surveillance of resistance markers in countries of malaria …
eradication efforts. To facilitate the surveillance of resistance markers in countries of malaria …
Whole genome sequencing-based drug resistance predictions of multidrug-resistant Mycobacterium tuberculosis isolates from Tanzania
PM Mbelele, C Utpatel, E Sauli… - JAC-antimicrobial …, 2022 - academic.oup.com
Background Rifampicin-or multidrug-resistant (RR/MDR) Mycobacterium tuberculosis
complex (MTBC) strains account for considerable morbidity and mortality globally. WGS …
complex (MTBC) strains account for considerable morbidity and mortality globally. WGS …