Cerebral iron deposition in neurodegeneration
Disruption of cerebral iron regulation appears to have a role in aging and in the
pathogenesis of various neurodegenerative disorders. Possible unfavorable impacts of iron …
pathogenesis of various neurodegenerative disorders. Possible unfavorable impacts of iron …
Elemental and chemically specific X-ray fluorescence imaging of biological systems
From the perspective of a chemist, biology confers a rich variety of roles on a number of
metal ions. It is widely agreed that a large fraction of the genomic output of living things …
metal ions. It is widely agreed that a large fraction of the genomic output of living things …
Role of copper in the onset of Alzheimer's disease compared to other metals
Alzheimer's disease (AD) is a neurodegenerative disorder that is characterized by amyloid
plaques in patients' brain tissue. The plaques are mainly made of β-amyloid peptides and …
plaques in patients' brain tissue. The plaques are mainly made of β-amyloid peptides and …
Neurotoxicity linked to dysfunctional metal ion homeostasis and xenobiotic metal exposure: redox signaling and oxidative stress
Significance: Essential metals such as copper, iron, manganese, and zinc play a role as
cofactors in the activity of a wide range of processes involved in cellular homeostasis and …
cofactors in the activity of a wide range of processes involved in cellular homeostasis and …
Copper toxicity links to pathogenesis of Alzheimer's disease and therapeutics approaches
HW Ejaz, W Wang, M Lang - International Journal of Molecular Sciences, 2020 - mdpi.com
Alzheimer's disease (AD) is an irreversible, age-related progressive neurological disorder,
and the most common type of dementia in aged people. Neuropathological lesions of AD …
and the most common type of dementia in aged people. Neuropathological lesions of AD …
Enhanced defense against ferroptosis ameliorates cognitive impairment and reduces neurodegeneration in 5xFAD mice
Oxidative damage including lipid peroxidation is widely reported in Alzheimer's disease
(AD) with the peroxidation of phospholipids in membranes being the driver of ferroptosis, an …
(AD) with the peroxidation of phospholipids in membranes being the driver of ferroptosis, an …
A Perspective–can copper complexes be developed as a novel class of therapeutics?
Although copper–ligand complexes appear to be promising as a new class of therapeutics,
other than the family of copper (II) coordination compounds referred to as casiopeínas these …
other than the family of copper (II) coordination compounds referred to as casiopeínas these …
Cu and Zn interactions with Aβ peptides: consequence of coordination on aggregation and formation of neurotoxic soluble Aβ oligomers
The coordination chemistry of transition metal ions (Fe, Cu, Zn) with the amyloid-β (Aβ)
peptides has attracted a lot of attention in recent years due to its repercussions in …
peptides has attracted a lot of attention in recent years due to its repercussions in …
Iron, copper, and zinc concentration in Aβ plaques in the APP/PS1 mouse model of Alzheimer's disease correlates with metal levels in the surrounding neuropil
SA James, QI Churches, MD de Jonge… - ACS chemical …, 2017 - ACS Publications
The metal ions of iron, copper, and zinc have long been associated with the aggregation of β-
amyloid (Aβ) plaques in Alzheimer's disease; an interaction that has been suggested to …
amyloid (Aβ) plaques in Alzheimer's disease; an interaction that has been suggested to …
Re‐evaluation of the existing health‐based guidance values for copper and exposure assessment from all sources
EFSA Scientific Committee, SJ More, V Bampidis… - EFSA …, 2023 - Wiley Online Library
Copper is an essential micronutrient and also a regulated product used in organic and in
conventional farming pest management. Both deficiency and excessive exposure to copper …
conventional farming pest management. Both deficiency and excessive exposure to copper …