Alternative precursor-mRNA splicing is a key mechanism for regulating gene expression in
mammals and is controlled by specialized RNA-binding proteins. The misregulation of …

A holy grail of regenerative medicine is to replenish the cells that are lost due to disease.
The adult mammalian central nervous system (CNS) has, however, largely lost such a …

Alternative splicing is prevalent in the mammalian brain. To interrogate the functional role of
alternative splicing in neural development, we analyzed purified neural progenitor cells …

While thousands of long noncoding RNAs (lncRNAs) have been identified, few lncRNAs that
control neural stem cell (NSC) behavior are known. Here, we identify Pinky (Pnky) as a …

Direct reprogramming of glia into neurons is a potentially promising approach for the
replacement of neurons lost to injury or neurodegenerative disorders. Knockdown of the …

Long noncoding RNAs (lncRNAs) are non-protein-coding RNA transcripts that exert a key
role in many cellular processes and have potential toward addressing disease etiology …

Polypyrimidine tract‐binding protein (PTB), as a member of the heterogeneous nuclear
ribonucleoprotein family, functions by rapidly shuttling between the nucleus and the …

The RNA-binding proteins PTBP1 and PTBP2 control programs of alternative splicing during
neuronal development. PTBP2 was found to maintain embryonic splicing patterns of many …

During both development and adulthood, the human brain expresses many thousands of
long noncoding RNAs (lncRNAs), and aberrant lncRNA expression has been associated …

Cell replacement therapy represents a promising approach for treating neurodegenerative
diseases. Contrary to the common addition strategy to generate new neurons from glia by …