Cholinesterase inhibitors as Alzheimer's therapeutics
K Sharma - Molecular medicine reports, 2019 - spandidos-publications.com
Alzheimer's disease (AD) is one of the most common forms of dementia. AD is a chronic
syndrome of the central nervous system that causes a decline in cognitive function and …
syndrome of the central nervous system that causes a decline in cognitive function and …
A review on cholinesterase inhibitors for Alzheimer's disease
P Anand, B Singh - Archives of pharmacal research, 2013 - Springer
Abstract Alzheimer's disease (AD), a progressive neurodegenerative disorder, is
characterized by the deficits in the cholinergic system and deposition of beta amyloid (Aβ) in …
characterized by the deficits in the cholinergic system and deposition of beta amyloid (Aβ) in …
New Acetylcholinesterase Inhibitors for Alzheimer′ s Disease
Acetylcholinesterase (AChE) remains a highly viable target for the symptomatic
improvement in Alzheimer′ s disease (AD) because cholinergic deficit is a consistent and …
improvement in Alzheimer′ s disease (AD) because cholinergic deficit is a consistent and …
Recent advances in the multitarget‐directed ligands approach for the treatment of Alzheimer's disease
With 27 million cases worldwide documented in 2006, Alzheimer's disease (AD) constitutes
an overwhelming health, social, economic, and political problem to nations. Unless a new …
an overwhelming health, social, economic, and political problem to nations. Unless a new …
Recent advances in the Friedlander reaction
J Marco-Contelles, E Pérez-Mayoral, A Samadi… - Chemical …, 2009 - ACS Publications
The quinoline ring system1-5 is present in a number of natural6 and synthetic products often
endowed with interesting pharmacological or physical properties. 7, 8 Consequently, a …
endowed with interesting pharmacological or physical properties. 7, 8 Consequently, a …
Acetylcholinesterase inhibitors as Alzheimer therapy: from nerve toxins to neuroprotection
Acetylcholinesterase is a member of the α/β hydrolase protein super family, with a significant
role in acetylcholine-mediated neurotransmission. Research in the modulators of AChEs …
role in acetylcholine-mediated neurotransmission. Research in the modulators of AChEs …
Amphiphilic distyrylbenzene derivatives as potential therapeutic and imaging agents for soluble and insoluble amyloid β aggregates in Alzheimer's disease
Alzheimer's Disease (AD) is the most common neurodegenerative disease, and efficient
therapeutic and early diagnostic agents for AD are still lacking. Herein, we report the …
therapeutic and early diagnostic agents for AD are still lacking. Herein, we report the …
Anti-cholinesterase hybrids as multi-target-directed ligands against Alzheimer's disease (1998–2018)
Alzheimer's disease (AD) is a genetically complex, progressive and irreversible
neurodegenerative disorder of the brain which involves multiple associated etiological …
neurodegenerative disorder of the brain which involves multiple associated etiological …
Multi-target-directed ligands in Alzheimer's disease treatment
M Bajda, N Guzior, M Ignasik… - Current medicinal …, 2011 - ingentaconnect.com
Among the various drug discovery methods, a very promising modern approach consists in
designing multi-target-directed ligands (MTDLs). This methodology has been specifically …
designing multi-target-directed ligands (MTDLs). This methodology has been specifically …
Multi-target-directed ligands and other therapeutic strategies in the search of a real solution for Alzheimer's disease
A Agis-Torres, M Sollhuber… - Current …, 2014 - ingentaconnect.com
The lack of an adequate therapy for Alzheimer's Disease (AD) contributes greatly to the
continuous growing amount of papers and reviews, reflecting the important efforts made by …
continuous growing amount of papers and reviews, reflecting the important efforts made by …