[HTML][HTML] IL-1 family members in cancer; two sides to every story
The IL-1 family of cytokines currently comprises of seven ligands with pro-inflammatory
activity (IL-1α and IL-1β, IL-18, IL-33, IL-36α, IL-36β, IL-36γ) as well as two ligands with anti …
activity (IL-1α and IL-1β, IL-18, IL-33, IL-36α, IL-36β, IL-36γ) as well as two ligands with anti …
Anti-inflammatory cytokines in endometriosis
WJ Zhou, HL Yang, J Shao, J Mei, KK Chang… - Cellular and molecular …, 2019 - Springer
Although the pathogenesis of endometriosis is not fully understood, it is often considered to
be an inflammatory disease. An increasing number of studies suggest that differential …
be an inflammatory disease. An increasing number of studies suggest that differential …
[HTML][HTML] Fungal mycobiome drives IL-33 secretion and type 2 immunity in pancreatic cancer
A Alam, E Levanduski, P Denz, HS Villavicencio… - Cancer cell, 2022 - cell.com
TH 2 cells and innate lymphoid cells 2 (ILC2) can stimulate tumor growth by secreting pro-
tumorigenic cytokines such as interleukin-4 (IL-4), IL-5, and IL-13. However, the …
tumorigenic cytokines such as interleukin-4 (IL-4), IL-5, and IL-13. However, the …
Tumor-initiating cells establish an IL-33–TGF-β niche signaling loop to promote cancer progression
S Taniguchi, A Elhance, A Van Duzer, S Kumar… - Science, 2020 - science.org
INTRODUCTION A small subset of tumor cells with long-term tumorigenic capacity, known
as tumor-initiating cells (TICs), play a pivotal role in cancer development and therapy …
as tumor-initiating cells (TICs), play a pivotal role in cancer development and therapy …
Inhibition of the dipeptidyl peptidase DPP4 (CD26) reveals IL-33-dependent eosinophil-mediated control of tumor growth
C Hollande, J Boussier, J Ziai, T Nozawa, V Bondet… - Nature …, 2019 - nature.com
Post-translational modification of chemokines mediated by the dipeptidyl peptidase DPP4
(CD26) has been shown to negatively regulate lymphocyte trafficking, and its inhibition …
(CD26) has been shown to negatively regulate lymphocyte trafficking, and its inhibition …
Interleukin‐33/ST2 axis promotes breast cancer growth and metastases by facilitating intratumoral accumulation of immunosuppressive and innate lymphoid cells
IP Jovanovic, NN Pejnovic… - … journal of cancer, 2014 - Wiley Online Library
The role of IL‐33/ST2 pathway in antitumor immunity is unclear. Using 4T1 breast cancer
model we demonstrate time‐dependent increase of endogenous IL‐33 at both the mRNA …
model we demonstrate time‐dependent increase of endogenous IL‐33 at both the mRNA …
[HTML][HTML] Role of IL-33 in inflammation and disease
AM Miller - Journal of inflammation, 2011 - Springer
Abstract Interleukin (IL)-33 is a new member of the IL-1 superfamily of cytokines that is
expressed by mainly stromal cells, such as epithelial and endothelial cells, and its …
expressed by mainly stromal cells, such as epithelial and endothelial cells, and its …
ST2/IL-33-dependent microglial response limits acute ischemic brain injury
Y Yang, H Liu, H Zhang, Q Ye, J Wang… - Journal of …, 2017 - Soc Neuroscience
ST2, a member of the interleukin (IL) 1 receptor family, and its ligand IL-33 play critical roles
in immune regulation and inflammatory responses. This study explores the roles of …
in immune regulation and inflammatory responses. This study explores the roles of …
IL-33 restricts tumor growth and inhibits pulmonary metastasis in melanoma-bearing mice through eosinophils
V Lucarini, G Ziccheddu, I Macchia, V La Sorsa… - …, 2017 - Taylor & Francis
The alarmin IL-33 is an IL-1 family member that stimulates pleiotropic immune reactions
depending on the target tissue and microenvironmental factors. In this study, we have …
depending on the target tissue and microenvironmental factors. In this study, we have …
IL-33/ST2 axis in inflammation and immunopathology
M Milovanovic, V Volarevic, G Radosavljevic… - Immunologic …, 2012 - Springer
Abstract Interleukin-33 (IL-33), a member of the IL-1 family of cytokines, binds to its plasma
membrane receptor, heterodimeric complex consisted of membrane-bound ST2L and IL-1R …
membrane receptor, heterodimeric complex consisted of membrane-bound ST2L and IL-1R …