Neural tube defects (NTDs) are common complex congenital malformations resulting from
failure of the neural tube closure during embryogenesis. It is established that folic acid …

The influence of folate nutritional status on various pregnancy outcomes has long been
recognized. Studies conducted in the 1950s and 1960s led to the recognition of prenatal …

Neural tube defects (NTDs) are common, severe congenital malformations whose causation
involves multiple genes and environmental factors. Although more than 200 genes are …

Spina bifida, anencephaly, and encephalocele are commonly grouped together and termed
neural tube defects (NTD). Failure of closure of the neural tube during development results …

Epidemiologic and mechanistic evidence suggests that folate is involved in colorectal
neoplasia. Some polymorphic genes involved in folate metabolism …

During the fifteen years since the bestselling first edition of Folate in Health and Disease
was published, there have been thousands of new research studies related to folate and its …

目的: 探讨编码叶酸代谢通路中关键酶的基因多态性与新生儿神经管缺陷(NTDs) 间的关联性,
及在部分中国女性人群中的分布特征, 从而指导孕期叶酸补充和风险监测. 方法 …

During the last decade critical new information has been published pertaining to folic acid
supplementation in the prevention of neural tube defects (NTDs) and other folic acid …

Background Methylenetetrahydrofolate reductase (MTHFR) C677T, A1298C and methionine
synthase reductase (MTRR) A66G polymorphisms are important genetic determinants for …

Background Folic acid taken in early pregnancy reduces risks for delivering offspring with
several congenital anomalies. The mechanism by which folic acid reduces risk is unknown …