Genomics, convergent neuroscience and progress in understanding autism spectrum disorder
More than a hundred genes have been identified that, when disrupted, impart large risk for
autism spectrum disorder (ASD). Current knowledge about the encoded proteins—although …
autism spectrum disorder (ASD). Current knowledge about the encoded proteins—although …
An overview of meningiomas
RA Buerki, CM Horbinski, T Kruser, PM Horowitz… - Future …, 2018 - Taylor & Francis
Meningiomas are the most common primary intracranial tumor. Important advances are
occurring in meningioma research. These are expected to accelerate, potentially leading to …
occurring in meningioma research. These are expected to accelerate, potentially leading to …
[HTML][HTML] Updated diagnostic criteria and nomenclature for neurofibromatosis type 2 and schwannomatosis: An international consensus recommendation
Abstract Purpose Neurofibromatosis type 2 (NF2) and schwannomatosis (SWN) are
genetically distinct tumor predisposition syndromes with overlapping phenotypes. We …
genetically distinct tumor predisposition syndromes with overlapping phenotypes. We …
Neurofibromatosis type 1
DH Gutmann, RE Ferner, RH Listernick… - Nature Reviews …, 2017 - nature.com
Neurofibromatosis type 1 is a complex autosomal dominant disorder caused by germline
mutations in the NF1 tumour suppressor gene. Nearly all individuals with neurofibromatosis …
mutations in the NF1 tumour suppressor gene. Nearly all individuals with neurofibromatosis …
Signaling pathways in brain tumors and therapeutic interventions
S Li, C Wang, J Chen, Y Lan, W Zhang… - … and Targeted Therapy, 2023 - nature.com
Brain tumors, although rare, contribute to distinct mortality and morbidity at all ages.
Although there are few therapeutic options for brain tumors, enhanced biological …
Although there are few therapeutic options for brain tumors, enhanced biological …
Role of Merlin/NF2 inactivation in tumor biology
AM Petrilli, C Fernández-Valle - Oncogene, 2016 - nature.com
Abstract Merlin (Moesin-ezrin-radixin-like protein, also known as schwannomin) is a tumor
suppressor protein encoded by the neurofibromatosis type 2 gene NF2. Loss of function …
suppressor protein encoded by the neurofibromatosis type 2 gene NF2. Loss of function …
[HTML][HTML] The hippo signaling pathway in development and cancer
D Pan - Developmental cell, 2010 - cell.com
First discovered in Drosophila, the Hippo signaling pathway is a conserved regulator of
organ size. Central to this pathway is a kinase cascade leading from the tumor suppressor …
organ size. Central to this pathway is a kinase cascade leading from the tumor suppressor …
[HTML][HTML] Spatial organization of Hippo signaling at the plasma membrane mediated by the tumor suppressor Merlin/NF2
Although Merlin/NF2 was discovered two decades ago as a tumor suppressor underlying
Neurofibromatosis type II, its precise molecular mechanism remains poorly understood …
Neurofibromatosis type II, its precise molecular mechanism remains poorly understood …
Organizing the cell cortex: the role of ERM proteins
RG Fehon, AI McClatchey, A Bretscher - Nature reviews Molecular cell …, 2010 - nature.com
Specialized membrane domains are an important feature of almost all cells. In particular,
they are essential to tissues that have a highly organized cell cortex, such as the intestinal …
they are essential to tissues that have a highly organized cell cortex, such as the intestinal …
[图书][B] DeVita, Hellman, and Rosenberg's cancer: principles & practice of oncology
VT DeVita, TS Lawrence, SA Rosenberg - 2008 - books.google.com
Acclaimed by the worldwide medical community as" a staple reference text in the medical
oncologist's library"(JAMA), DeVita, Hellman, and Rosenberg's Cancer: Principles and …
oncologist's library"(JAMA), DeVita, Hellman, and Rosenberg's Cancer: Principles and …