Lung macrophages play important roles in the maintenance of homeostasis, pathogen
clearance and immune regulation. The different types of pulmonary macrophages and their …

Alveolar macrophages (AMs) are the sentinel cells of the alveolar space, maintaining
homeostasis, fending off pathogens, and controlling lung inflammation. During acute lung …

In vitro studies have associated oxidative phosphorylation (OXPHOS) with anti-inflammatory
macrophages, whereas pro-inflammatory macrophages rely on glycolysis. However, the …

In the lungs, macrophages constitute the first line of defense against pathogens and foreign
bodies and play a fundamental role in maintaining tissue homeostasis. Activated …

Environmental microbial triggers shape the development and functionality of the immune
system. Alveolar macrophages (AMs), tissue-resident macrophages of the lungs, are in …

Airway macrophages (AMs) play key roles in the maintenance of lung immune tolerance.
Tissue tailored, highly specialised and strategically positioned, AMs are critical sentinels of …

Adipose thermogenesis is repressed in obesity, reducing the homeostatic capacity to
compensate for chronic overnutrition. Inflammation inhibits adipose thermogenesis, but little …

Clearance of apoptotic cells, or" efferocytosis," is essential for diverse processes including
embryonic development, tissue turnover, organ regeneration, and immune cell …

Macrophages residing in various tissue types are unique in terms of their anatomical
locations, ontogenies, developmental pathways, gene expression patterns, and …

Idiopathic pulmonary fibrosis is a fatal interstitial lung disease characterized by the TGF-β
(transforming growth factor-β)–dependent differentiation of lung fibroblasts into …