Aminoacyl-tRNA synthetases
MAR Gomez, M Ibba - Rna, 2020 - rnajournal.cshlp.org
The aminoacyl-tRNA synthetases are an essential and universally distributed family of
enzymes that plays a critical role in protein synthesis, pairing tRNAs with their cognate …
enzymes that plays a critical role in protein synthesis, pairing tRNAs with their cognate …
Oxidative stress in bacteria and the central dogma of molecular biology
M Fasnacht, N Polacek - Frontiers in Molecular Biosciences, 2021 - frontiersin.org
Ever since the “great oxidation event,” Earth's cellular life forms had to cope with the danger
of reactive oxygen species (ROS) affecting the integrity of biomolecules and hampering …
of reactive oxygen species (ROS) affecting the integrity of biomolecules and hampering …
Aminoacyl-tRNA synthesis and translational quality control
Translating the 4-letter code of RNA into the 22-letter alphabet of proteins is a central feature
of cellular life. The fidelity with which mRNA is translated during protein synthesis is …
of cellular life. The fidelity with which mRNA is translated during protein synthesis is …
Severe oxidative stress induces protein mistranslation through impairment of an aminoacyl-tRNA synthetase editing site
Oxidative stress arises from excessive reactive oxygen species (ROS) and affects organisms
of all three domains of life. Here we present a previously unknown pathway through which …
of all three domains of life. Here we present a previously unknown pathway through which …
Aminoacyl-tRNA synthetases: Structure, function, and drug discovery
Aminoacyl-tRNA synthetases (AARSs) are the enzymes that catalyze the aminoacylation
reaction by covalently linking an amino acid to its cognate tRNA in the first step of protein …
reaction by covalently linking an amino acid to its cognate tRNA in the first step of protein …
Synthetic and editing mechanisms of aminoacyl-tRNA synthetases
JJ Perona, I Gruic-Sovulj - Aminoacyl-tRNA synthetases in biology and …, 2014 - Springer
Aminoacyl-tRNA synthetases (aaRS) ensure the faithful transmission of genetic information
in all living cells. The 24 known aaRS families are divided into 2 structurally distinct classes …
in all living cells. The 24 known aaRS families are divided into 2 structurally distinct classes …
Quality control in aminoacyl-tRNA synthesis: its role in translational fidelity
SS Yadavalli, M Ibba - Advances in protein chemistry and structural biology, 2012 - Elsevier
Accurate translation of mRNA into protein is vital for maintenance of cellular integrity.
Translational fidelity is achieved by two key events: synthesis of correctly paired aminoacyl …
Translational fidelity is achieved by two key events: synthesis of correctly paired aminoacyl …
Structural diversity and protein engineering of the aminoacyl-tRNA synthetases
JJ Perona, A Hadd - Biochemistry, 2012 - ACS Publications
Aminoacyl-tRNA synthetases (aaRS) are the enzymes that ensure faithful transmission of
genetic information in all living cells, and are central to the developing technologies for …
genetic information in all living cells, and are central to the developing technologies for …
The crystal structure of leucyl-tRNA synthetase complexed with tRNALeu in the post-transfer–editing conformation
Leucyl-tRNA synthetase (LeuRS) has a specific post-transfer editing activity directed against
mischarged isoleucine and similar noncognate amino acids. We describe the post-transfer …
mischarged isoleucine and similar noncognate amino acids. We describe the post-transfer …
How evolution shapes enzyme selectivity–lessons from aminoacyl‐tRNA synthetases and other amino acid utilizing enzymes
DS Tawfik, I Gruic‐Sovulj - The FEBS journal, 2020 - Wiley Online Library
Aminoacyl‐tRNA synthetases (AARSs) charge tRNA with their cognate amino acids. Many
other enzymes use amino acids as substrates, yet discrimination against noncognate amino …
other enzymes use amino acids as substrates, yet discrimination against noncognate amino …