The study of pain development has come into its own. Reaping the rewards of years of
developmental and molecular biology, it has now become possible to translate fundamental …

Objective To develop evidence-based guidelines for preventing or treating neonatal pain
and its adverse consequences. Compared with older children and adults, neonates are …

Invasive procedures that would be painful in children and adults are frequently performed on
infants admitted to the neonatal intensive care unit. This article discusses sensory responses …

The protooncogene c-fos is rapidly activated after noxious stimuli to express the protein Fos
in spinal dorsal horn neurons that are in the 'correct'locations for nociceptive information …

Irritable bowel syndrome is a functional gastrointestinal disorder, with stress playing a major
role in onset and exacerbation of symptoms such as abdominal pain and altered bowel …

Aim: Leg massage could inhibit the transmission of pain by 'closing the gate'or by activating
the endogenous opioid pathway to decrease nociceptive transmission of pain associated …

Irritable bowel syndrome (IBS) is one of the most common gastrointestinal disorders,
characterized by abdominal pain and disturbed defecation that cannot be explained by …

For a long time, the capacity of the newborn infant to feel pain was denied. Today it is clear
that the nociceptive system, even if still immature, is functional enough in the newborn infant …

The impact of early life events is increasingly becoming apparent, as studies investigate how
early childhood can shape long‐term physiology and behaviour. Fibromyalgia (FM), which is …

We have previously shown that colon irritation (CI) in neonates results in chronic visceral
hypersensitivity in adult rats, associated with central neuronal sensitization in the absence of …