BACKGROUND Childhood cancer incidence and survivorship are both on the rise.
However, many lifesaving treatments threaten the prepubertal testis. Cryopreservation of …

Increasing rates of male infertility have led to a greater need for relevant model systems to
gain further insight into male fertility and its failings. Spermatogenesis and hormone …

STUDY QUESTION Can the organ culture method be applied to both fresh and
cryopreserved human (pre) pubertal testicular tissue as a strategy for in vitro …

Testicular organoid models are tools to study testicular physiology, development, and
spermatogenesis in vitro. However, few side-by-side comparisons of organoid generation …

Simple Summary Oncofertility refers to medical interventions aimed at preserving the fertility
of cancer patients, particularly those undergoing treatments like chemotherapy and radiation …

The increasing cure rate of cancer has led to a vast population of survivors having to face
the late adverse effects of oncological treatments, with fertility impairment being one of the …

Survival rates for children and adolescents diagnosed with malignancy have been steadily
increasing due to advances in oncology treatments. These treatments can have a toxic effect …

Since the birth of the first child conceived via in vitro fertilization 40 years ago, fertility
treatments and assisted reproductive technology have allowed many couples to reach their …

Background Cancer treatment of prepubertal patients impacts future fertility due to the
abolition of spermatogonial stem cells (SSCs). In macaques, spermatogenesis could be …

Background In male pre‐pubertal cancer patients, radiation and chemotherapy impact future
fertility by eradication of spermatogonial stem cells (SSCs). In macaques, spermatogenesis …