Abstract Chalcone or (E)-1, 3-diphenyl-2-propene-1-one scaffold remained a fascination
among researchers in the 21st century due to its simple chemistry, ease of synthesis and a …

Multidrug resistance (MDR) in cancer cells is the development of resistance to a variety of
structurally and functionally nonrelated anticancer drugs. This phenomenon has become a …

Natural or synthetic chalcones with different substituents have revealed a variety of
biological activities that may benefit human health. The underlying mechanisms of action …

Cancer is a multistage and heterogeneous disease caused by the accumulation of genetic
and epigenetic changes. As polyphenols exhibit antitumor properties, they are considered to …

Breast cancer resistance protein (BCRP) is a protein belonging to the ATP-binding cassette
(ABC) transporter superfamily that has clinical relevance due to its multi-drug resistance …

Potent ABCG2 inhibitors were recently identified as asymmetric chromones with different
types of substituents. We here synthesized symmetric bis-chalcones that were differently …

Bavachalcone is an important active component of the traditional Chinese medicine Fructus
Psoraleae. The inhibitory effect of bavachalcone on α-glucosidase activity is reported for the …

Introduction: Drug transporters are now recognized as major players involved in
pharmacokinetics and toxicology. Methods for assessing their activity are important to …

A series of chalcones substituted by a quinoxaline unit at the B-ring were synthesized and
tested as inhibitors of breast cancer resistance protein-mediated mitoxantrone efflux. These …

Natural products form a significant portion of medicinal agents that are currently used for the
management of cancer. All these natural products have unique structures along with diverse …