Wnts are secreted, lipid-modified proteins that bind to different receptors on the cell surface
to activate canonical or non-canonical Wnt signaling pathways, which control various …

Prostate cancer is a hormone-driven disease and its tumor cell growth highly relies on
increased androgen receptor (AR) signaling. Therefore, targeted therapy directed against …

Lineage plasticity is implicated in treatment resistance in multiple cancers. In lung
adenocarcinomas (LUAD) amenable to targeted therapy, transformation to small cell lung …

Abstract β‐catenin‐mediated Wnt signaling is an ancient cell‐communication pathway in
which β‐catenin drives the expression of certain genes as a consequence of the trigger …

Cell plasticity in cancer cell populations - PMC Back to Top Skip to main content NIH NLM
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Globally, prostate cancer ranks second in cancer burden of the men. It occurs more
frequently in black men compared to white or Asian men. Usually, high rates exist for men …

There is increasing evidence indicating the significant role of DDX5 (also called p68), acting
as a master regulator and a potential biomarker and target, in tumorigenesis, proliferation …

Developmental phenotypic changes can evolve under selection imposed by age-and size-
related ecological differences. Many of these changes occur through programmed …

Neuroendocrine prostate cancer (NEPC) is a lethal prostate cancer subtype arising as a
consequence of more potent androgen receptor (AR) targeting in castration-resistant …

The forkhead box transcription factor FOXQ1 contributes to the pathogenesis of carcinomas.
In colorectal cancers, FOXQ1 promotes tumour metastasis by inducing epithelial-to …