Malaria is a significant public health problem in more than 100 countries and causes an
estimated 200 million new infections every year. Despite the significant effort to eradicate …

The discovery of melatonin and its derivatives as antioxidants has stimulated a very large
number of studies which have, virtually uniformly, documented the ability of these molecules …

As next-generation artificial enzymes, nanozymes have shown great promise for tumor
catalytic therapy. In particular, their peroxidase-like activity has been employed to catalyze …

Single-atom nanozymes (SAzymes), with individually isolated metal atom as active sites,
have shown tremendous potential as enzyme-based drugs for enzymatic therapy. However …

Caveolins are a family of membrane-bound scaffolding proteins that compartmentalize and
negatively regulate signal transduction. Recent studies have implicated a loss of caveolin-1 …

Cancer cells do not exist as pure homogeneous populations in vivo. Instead they are
embedded in “cancer cell nests” that are surrounded by stromal cells, especially cancer …

Cancer cells show a broad spectrum of bioenergetic states, with some cells using aerobic
glycolysis while others rely on oxidative phosphorylation as their main source of energy. In …

The development of an effective malaria vaccine remains a global public health priority.
Less than 0.5% of the Plasmodium falciparum genome has been assessed as potential …

It is now widely recognized that the tumor microenvironment promotes cancer cell growth
and metastasis via changes in cytokine secretion and extracellular matrix remodeling …

Background Liver involvement in severe Plasmodium falciparum infection is commonly a
significant cause of morbidity and mortality among humans. The clinical presentation of …