Reactive oxygen species (ROS), a group of highly reactive ions and molecules, are
increasingly being appreciated as powerful signaling molecules involved in the regulation of …

There is highly credible evidence that melatonin mitigates cancer at the initiation,
progression and metastasis phases. In many cases, the molecular mechanisms …

Reactive oxygen species (ROS) are constantly generated and eliminated in the biological
system, and play important roles in a variety of normal biochemical functions and abnormal …

Mitochondria play important roles in cellular energy metabolism, free radical generation, and
apoptosis. Defects in mitochondrial function have long been suspected to contribute to the …

Cancer cells are under intrinsic increased oxidative stress and vulnerable to free radical-
induced apoptosis. Here, we report a strategy to hinder mitochondrial electron transport and …

Programmed cell death (PCD) is a major component of normal development, preservation of
tissue homeostasis, and elimination of damaged cells. Many studies have subdivided PCD …

The etiology of Parkinson's disease (PD) is attributed to both environmental and genetic
factors. The development of PD reportedly involves mitochondrial impairment, oxidative …

Temozolomide (TMZ) is an alkylating agent used for treating gliomas. Chemoresistance is a
severe limitation to TMZ therapy; there is a critical need to understand the underlying …

Endometriosis is associated with inflammatory reaction, and reactive oxidative species
(ROS) are highly pro-inflammatory factors. Mitochondria are responsible for the production …

A clinically-related animal model of Parkinson's disease (PD) may enable the elucidation of
the etiology of the disease and assist the development of medications. However, none of the …