Background Recruitment for clinical trials continues to be a challenge, as patient recruitment
is the single biggest cause of trial delays. Around 80% of trials fail to meet the initial …

Background: Young people are at risk of poor sexual health and are, therefore, in need of
comprehensive, effective sexual health education. Young people are confident and constant …

Background Recruiting and retaining participants in randomised controlled trials (RCTs) is
challenging. Digital tools, such as social media, data mining, email or text-messaging, could …

Background Internet-accessed sexually transmitted infection testing (e-STI testing) is
increasingly available as an alternative to testing in clinics. Typically this testing modality …

Background The internet is an increasingly popular tool in family and child research that is
argued to pose new ethical challenges, yet few studies have systematically assessed the …

Background Genital infections caused by Chlamydia trachomatis are the most prevalent
bacterial sexually transmitted infection worldwide. Screening of sexually active young adults …

Aims To evaluate, using quantitative and qualitative approaches, published data on the
design and conduct of decentralised clinical trials (DCTs). Methods We searched MEDLINE …

There has been a proliferation of digital sexual health interventions targeting adolescents;
however, limited evaluative reviews have compared the effectiveness of multiple digital tools …

Objectives Children of anxious parents are at high risk of anxiety disorders themselves. The
evidence suggests that this is due to environmental rather than genetic factors. However, we …

Background Retention of participants is essential to ensure the statistical power and internal
validity of clinical trials. Poor participant retention reduces power and can bias the estimates …