RecBCD enzyme and the repair of double-stranded DNA breaks
MS Dillingham, SC Kowalczykowski - Microbiology and Molecular …, 2008 - Am Soc Microbiol
SUMMARY The RecBCD enzyme of Escherichia coli is a helicase-nuclease that initiates the
repair of double-stranded DNA breaks by homologous recombination. It also degrades …
repair of double-stranded DNA breaks by homologous recombination. It also degrades …
Molecular motors: a theorist's perspective
AB Kolomeisky, ME Fisher - Annu. Rev. Phys. Chem., 2007 - annualreviews.org
Individual molecular motors, or motor proteins, are enzymatic molecules that convert
chemical energy, typically obtained from the hydrolysis of ATP (adenosine triphosphate) …
chemical energy, typically obtained from the hydrolysis of ATP (adenosine triphosphate) …
[HTML][HTML] UvrD helicase unwinds DNA one base pair at a time by a two-part power stroke
JY Lee, W Yang - Cell, 2006 - cell.com
Helicases use the energy derived from nucleoside triphosphate hydrolysis to unwind double
helices in essentially every metabolic pathway involving nucleic acids. Earlier crystal …
helices in essentially every metabolic pathway involving nucleic acids. Earlier crystal …
Non-hexameric DNA helicases and translocases: mechanisms and regulation
Helicases and nucleic acid translocases are motor proteins that have essential roles in
nearly all aspects of nucleic acid metabolism, ranging from DNA replication to chromatin …
nearly all aspects of nucleic acid metabolism, ranging from DNA replication to chromatin …
RNA translocation and unwinding mechanism of HCV NS3 helicase and its coordination by ATP
Helicases are a ubiquitous class of enzymes involved in nearly all aspects of DNA and RNA
metabolism. Despite recent progress in understanding their mechanism of action, limited …
metabolism. Despite recent progress in understanding their mechanism of action, limited …
[HTML][HTML] Mechanisms of helicases
SS Patel, I Donmez - Journal of Biological Chemistry, 2006 - ASBMB
Helicase protein was first discovered in Escherichia coli in 1976 (1, 2). Since then RNA and
DNA helicases with diverse functions have been found in all organisms. Helicases couple …
DNA helicases with diverse functions have been found in all organisms. Helicases couple …
[HTML][HTML] Förster resonance energy transfer and protein-induced fluorescence enhancement as synergetic multi-scale molecular rulers
Advanced microscopy methods allow obtaining information on (dynamic) conformational
changes in biomolecules via measuring a single molecular distance in the structure. It is …
changes in biomolecules via measuring a single molecular distance in the structure. It is …
[HTML][HTML] Sauna bathing is associated with reduced cardiovascular mortality and improves risk prediction in men and women: a prospective cohort study
Background Previous evidence indicates that sauna bathing is related to a reduced risk of
fatal cardiovascular disease (CVD) events in men. The aim of this study was to investigate …
fatal cardiovascular disease (CVD) events in men. The aim of this study was to investigate …
[HTML][HTML] A nonuniform stepping mechanism for E. coli UvrD monomer translocation along single-stranded DNA
EJ Tomko, CJ Fischer, A Niedziela-Majka, TM Lohman - Molecular cell, 2007 - cell.com
E. coli UvrD is an SF1 helicase involved in several DNA metabolic processes. Although a
UvrD dimer is needed for helicase activity, a monomer can translocate with 3′ to 5 …
UvrD dimer is needed for helicase activity, a monomer can translocate with 3′ to 5 …
Structure and mechanisms of SF1 DNA helicases
Superfamily I is a large and diverse group of monomeric and dimeric helicases defined by a
set of conserved sequence motifs. Members of this class are involved in essential processes …
set of conserved sequence motifs. Members of this class are involved in essential processes …