Cancer stem cells (CSCs) show a self-renewal capacity and differentiation potential that
contribute to tumor progression and therapy resistance. However, the underlying processes …

Cancer stem-like cells (CSCs), a subpopulation of cancer cells, possess remarkable
capability in proliferation, self-renewal, and differentiation. Their presence is recognized as a …

Resistance to cancer therapies has been a commonly observed phenomenon in clinical
practice, which is one of the major causes of treatment failure and poor patient survival. The …

EGFR is a prototypical receptor tyrosine kinase that is overexpressed in multiple cancers
including head and neck squamous cell carcinoma (HNSCC). The standard of care for …

Innate and acquired resistance towards the conventional therapeutic regimen imposes a
significant challenge for the successful management of cancer for decades. In patients with …

Tumors are intricate ecosystems containing malignant components that generate adaptive
and evolutionarily driven abnormal tissues. Through self-renewal and differentiation …

Breast cancer (BC) is one of the most common malignant tumors in women globally, and its
occurrence has surpassed lung cancer and become the biggest threat for women. At …

Gene therapy is emerging as a valid method for the treatment of ovarian cancer, including
small interfering RNA (siRNA). Although it is so powerful, few targeting efficient gene …

Background Granulocyte-macrophage colony stimulating factor (GM-CSF) is a cytokine that
is used as an immunopotentiator for anti-tumor therapies in recent years. We found that …

The cancer stem cell model claims that the initiation, maintenance, and growth of a tumor
are driven by a small population of cancer cells termed cancer stem cells. Cancer stem cells …