The MHC locus and genetic susceptibility to autoimmune and infectious diseases
In the past 50 years, variants in the major histocompatibility complex (MHC) locus, also
known as the human leukocyte antigen (HLA), have been reported as major risk factors for …
known as the human leukocyte antigen (HLA), have been reported as major risk factors for …
Genome-wide analysis provides genetic evidence that ACE2 influences COVID-19 risk and yields risk scores associated with severe disease
JE Horowitz, JA Kosmicki, A Damask, D Sharma… - Nature …, 2022 - nature.com
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) enters human host cells
via angiotensin-converting enzyme 2 (ACE2) and causes coronavirus disease 2019 (COVID …
via angiotensin-converting enzyme 2 (ACE2) and causes coronavirus disease 2019 (COVID …
Host genetic determinants of hepatitis B virus infection
Z Zhang, C Wang, Z Liu, G Zou, J Li, M Lu - Frontiers in genetics, 2019 - frontiersin.org
Chronic hepatitis B virus (HBV) infection is still a major health problem worldwide. Recently,
a great number of genetic studies based on single nucleotide polymorphisms (SNPs) and …
a great number of genetic studies based on single nucleotide polymorphisms (SNPs) and …
[PDF][PDF] The genetic architecture of the human immune system: a bioresource for autoimmunity and disease pathogenesis
M Roederer, L Quaye, M Mangino, MH Beddall… - Cell, 2015 - cell.com
Despite recent discoveries of genetic variants associated with autoimmunity and infection,
genetic control of the human immune system during homeostasis is poorly understood. We …
genetic control of the human immune system during homeostasis is poorly understood. We …
A review of HLA allele and SNP associations with highly prevalent infectious diseases in human populations
A Sanchez-Mazas - Swiss medical weekly, 2020 - smw.ch
Human leucocyte antigen (HLA) alleles and single nucleotide polymorphisms (SNPs) lying
in the HLA region are known to be associated with several infectious diseases among which …
in the HLA region are known to be associated with several infectious diseases among which …
Polymorphisms within DIO2 and GADD45A genes increase the risk of liver disease progression in chronic hepatitis b carriers
The study enrolled 284 patients with chronic hepatitis B virus infection. Participants included
people with mild fibrotic lesions (32.5%), moderate to severe fibrotic lesions (27.5%) …
people with mild fibrotic lesions (32.5%), moderate to severe fibrotic lesions (27.5%) …
The hepatitis B virus-associated tumor microenvironment in hepatocellular carcinoma
P Yang, GJ Markowitz, XF Wang - National science review, 2014 - academic.oup.com
In contrast to a majority of cancer types, the initiation of hepatocellular carcinoma (HCC) is
intimately associated with a chronically diseased liver tissue, with one of the most prevalent …
intimately associated with a chronically diseased liver tissue, with one of the most prevalent …
Immunopathogenesis of HBV infection
J Wu, M Han, J Li, X Yang, D Yang - Hepatitis B Virus Infection: Molecular …, 2020 - Springer
More than 95% of adult infected with HBV show acute self-limited infection and eventually
eliminate the virus. In contrast, about 90% of people exposed to HBV in early childhood …
eliminate the virus. In contrast, about 90% of people exposed to HBV in early childhood …
Genetic susceptibility to infectious diseases: Current status and future perspectives from genome-wide approaches
A Mozzi, C Pontremoli, M Sironi - Infection, genetics and evolution, 2018 - Elsevier
Genome-wide association studies (GWASs) have been widely applied to identify genetic
factors that affect complex diseases or traits. Presently, the GWAS Catalog includes> 2800 …
factors that affect complex diseases or traits. Presently, the GWAS Catalog includes> 2800 …
[HTML][HTML] Host genetic factors affecting hepatitis B infection outcomes: Insights from genome-wide association studies
IM Akcay, S Katrinli, K Ozdil, GD Doganay… - World journal of …, 2018 - ncbi.nlm.nih.gov
The clinical outcome of hepatitis B virus (HBV) infection depends on the success or failure of
the immune responses to HBV, and varies widely among individuals, ranging from …
the immune responses to HBV, and varies widely among individuals, ranging from …