Type 2 diabetes mellitus (T2DM) is a global epidemic that poses a major challenge to health-
care systems. Improving metabolic control to approach normal glycaemia (where practical) …

Abstract α-Amino nitrile compounds have a profound impact on bio-chemical sciences, as
they have been prepared from inexpensive starting materials and have become valuable …

DPP-4 inhibition is an interesting line of therapy for treating Type 2 Diabetes Mellitus (T2DM)
and is based on promoting the incretin effect. Here, the authors have presented a brief …

Type 2 diabetes (T2DM) is a complex disease combining defects in insulin secretion and
insulin action. New compounds have been developed for improving glucose‐induced …

Type 2 diabetes mellitus (T2DM) is a worldwide public health challenge. Despite the
availability of many antidiabetes agents and pharmacotherapies targeting cardiovascular …

Patients with type 2 diabetes mellitus (T2DM) are generally treated with many
pharmacological compounds and are exposed to a high risk of drug-drug interactions …

Aim: Endothelial cell (EC) dysfunction contributes to insulin resistance in diabetes and is
characterized by reduced nitric oxide (NO) release, increased nitroxidative stress and …

Diabetes is a fast growing chronic metabolic disorder around the world. Dipeptidyl peptidase-
4 (DPP-4) is a new promising target during type 2 diabetes glycemic control. Thus, a number …

Type 2 diabetes mellitus traditionally has been characterized by insulin resistance and β‐
cell dysfunction, leading to hyperglycemia and eventual micro‐and macrovascular …

Objective: Therapeutic options are limited for diabetes patients with renal disease. This
report presents 52‐week results from a study assessing the dipeptidyl peptidase‐4 inhibitor …