[HTML][HTML] Western diet as a trigger of Alzheimer's disease: From metabolic syndrome and systemic inflammation to neuroinflammation and neurodegeneration

A Więckowska-Gacek, A Mietelska-Porowska… - Ageing research …, 2021 - Elsevier
An excess of saturated fatty acids and simple sugars in the diet is a known environmental
risk factor of Alzheimer's disease (AD) but the holistic view of the interacting processes …

The link between Alzheimer disease and metabolic syndrome: a mutual relationship and long rigorous investigation

HM Al-Kuraishy, MS Jabir, AK Albuhadily… - Ageing Research …, 2023 - Elsevier
It has been illustrated that metabolic syndrome (MetS) is associated with Alzheimer disease
(AD) neuropathology. Components of MetS including central obesity, hypertension, insulin …

Ginsenoside Rg1 improves Alzheimer's disease by regulating oxidative stress, apoptosis, and neuroinflammation through Wnt/GSK‐3β/β‐catenin signaling pathway

Y Yang, L Wang, C Zhang, Y Guo, J Li… - Chemical Biology & …, 2022 - Wiley Online Library
Alzheimer's disease (AD) is a chronic neurodegenerative disorder that can cause cognitive
impairment. Ginsenoside Rg1 (Rg1) has a significant neuroprotective effect on animals with …

Insulin resistance as the molecular link between diabetes and Alzheimer's disease

MMI Abdalla - World Journal of Diabetes, 2024 - pmc.ncbi.nlm.nih.gov
Diabetes mellitus (DM) and Alzheimer's disease (AD) are two major health concerns that
have seen a rising prevalence worldwide. Recent studies have indicated a possible link …

Relationship between metabolic syndrome and bone health–an evaluation of epidemiological studies and mechanisms involved

KY Chin, SK Wong, SO Ekeuku… - … , Metabolic Syndrome and …, 2020 - Taylor & Francis
Metabolic syndrome (MetS) and osteoporosis are two medical problems plaguing the
ageing populations worldwide. Though seemingly distinctive to each other, metabolic …

Insulin resistance and bioenergetic manifestations: Targets and approaches in Alzheimer's disease

VK Sharma, TG Singh - Life Sciences, 2020 - Elsevier
Aim Insulin has a well-established role in cognition, neuronal detoxification and synaptic
plasticity. Insulin transduction affect neurotransmitter functions, influence bioenergetics and …

Metabolic diffusion in Neuropathologies: the relevance of Brain-Liver Axis

S Vegas-Suárez, J Simón, ML Martínez-Chantar… - Frontiers in …, 2022 - frontiersin.org
Chronic liver diseases include a broad group of hepatic disorders from different etiologies
and with varying degrees of progression and severity. Among them, non-alcoholic fatty …

Shared signaling pathways in Alzheimer's and metabolic disease may point to new treatment approaches

J Suresh, IW Khor, P Kaur, HL Heng, F Torta… - The FEBS …, 2021 - Wiley Online Library
'A peculiar severe disease process of the cerebral cortex'are the exact words used by A.
Alzheimer in 1906 to describe a patient's increasingly severe condition of memory loss …

Wnt signaling rescues amyloid beta-induced gut stem cell loss

P Kaur, EHZ Chua, WK Lim, J Liu, N Harmston… - Cells, 2022 - mdpi.com
Patients with Alzheimer's disease suffer from a decrease in brain mass and a prevalence of
amyloid-β plaques. These plaques are thought to play a role in disease progression, but …

Targeting hypercoagulation to alleviate Alzheimer's disease progression in metabolic syndrome

S Khan, S Pati, S Singh, M Akhtar, P Khare… - International Journal of …, 2022 - nature.com
Abstract Introduction Metabolic Syndrome (MetS) constitutes an important risk factor for
Alzheimer's disease (AD); however, the mechanism linking these two disorders has not …