B cells and the antibodies they produce have a deeply penetrating influence on human
physiology. Here, we review current understanding of how B cell responses are initiated; the …

The lung is the organ with the highest vascular density in the human body. It is therefore
perceivable that the endothelium of the lung contributes significantly to the circulation of …

Allergic inflammation is due to a complex interplay between several inflammatory cells,
including mast cells, basophils, lymphocytes, dendritic cells, eosinophils, and sometimes …

Exposure to environmental antigens, such as house dust mite (HDM), often leads to T helper
2 (Th2) cell-driven allergic responses. However, the mechanisms underlying the …

Allergic asthma is a common airway inflammatory disease in which B cells play important
roles through IgE production and antigen presentation. SNP (single nucleotide …

Alloimmunity to mismatched donor HLA-Ags and autoimmunity to self-Ags have been
hypothesized to play an important role in immunopathogenesis of chronic rejection of …

The response to respiratory syncytial virus (RSV), negative strand ssRNA virus, depends
upon the ability to recognize specific pathogen-associated targets. In the current study, the …

Abstract This Brief Review delves into B cell responses in the context of allergy. The primary
contribution of B cells to allergy is the production of IgE, the Ab isotype that triggers …

We have demonstrated that modifying the tumor microenvironment through intratumoral
administration of adenoviral vectors (Ad) encoding the conditional cytotoxic molecule, ie …

Activated neutrophil-derived exosomes reportedly contribute to the proliferation of airway
smooth muscle cells (ASMCs), thereby aggravating the airway wall remodeling during …