Phagocytosis, the regulated uptake of large particles (> 0.5 μm in diameter), is essential for
tissue homeostasis and is also an early, critical component of the innate immune response …

Engulfment and destruction of invading microorganisms by phagocytosis are critical
components of the innate immune response. In addition, phagocytosis is also required for …

The microvascular endothelial cell monolayer localized at the critical interface between the
blood and vessel wall has the vital functions of regulating tissue fluid balance and supplying …

The production and deployment of phagocytes are central functions of the hematopoietic
system. In the 1950s, radioisotopic studies demonstrated the high prodution rate and short …

The phagocytic response of innate immune cells such as macrophages is defined by the
activation of complex signaling networks that are stimulated by microbial contact. Many …

The process of engulfing a foreign particle–phagocytosis–is of fundamental importance for a
wide diversity of organisms. From simple unicellular organisms that use phagocytosis to …

Phagocytosis is an evolutionarily conserved process utilized by many cells to ingest
microbial pathogens, and apoptotic and necrotic corpses. Recent investigation has revealed …

Phagocytosis of foreign cells or particles by macrophages is a rapid process that is
inefficient when faced with “self” cells that display CD47—although signaling mechanisms in …

Interactions between the crystallizable fragment (Fc) domain of antibodies and a plethora of
cellular Fc receptors (FcRs) or soluble proteins form a critical link between humoral and …

Src homology 2 domain-containing protein tyrosine phosphatase (SHP) substrate-1 (SHPS-
1) is a transmembrane protein that is expressed predominantly in macrophages. Its …