Publisher Summary This chapter discusses the role of free radicals and catalytic metal ions
in human disease. The importance of transition metal ions in mediating oxidant damage …

A major portion of the toxicity of hydrogen peroxide in Escherichia coli is attributed to DNA
damage mediated by a Fenton reaction that generates active forms of hydroxyl radicals from …

Hydroxyl radicals, generated by reaction of an iron-EDTA complex with H2O2 in the
presence of ascorbic acid, attack deoxyribose to form products that, upon heating with …

When cells are exposed to oxidative stress, DNA damage frequently occurs. The molecular
mechanisms causing this damage may include activation of nucleases and direct reaction of …

The ability of zinc to retard oxidative processes has been recognized for many years. In
general, the mechanism of antioxidation can be divided into acute and chronic effects …

If direct chemical reactions of 0; are unlikely to account for most of the damage done by
aqueous O;-generating systems, then what does? Singlet Oz is an unlikely candidate-there …

Methionine (Met) is one of the most readily oxidized amino acid constituents of proteins. It is
attacked by H2O2, hydroxyl radicals, hypochlorite, chloramines, and peroxynitrite, all these …

Numerous transition metal ions and their complexes in their lower oxidation states (L m M
n+) were found to have the oxidative features of the Fenton reagent, and, therefore, the …

1.2. Hydrogen Peroxide 1.3. Hydroxyl Radical and HO 2. Radical 1.4. Hydroxyl Radical
Production in Superoxide-Generating and Other Biological Systems

“Footprinting” refers to assays that examine ligand binding and conformational changes by
determining the solvent accessibility of the backbone, bases, or side chain structures of …