Thrombin is a Na+-activated allosteric serine protease of the chymotrypsin family involved in
coagulation, inflammation, cell protection, and apoptosis. Increasingly, the role of thrombin …

Gliomas encompass highly invasive primary central nervous system (CNS) tumours of glial
cell origin with an often-poor clinical prognosis. Of all gliomas, glioblastoma is the most …

The neuro-glial interface extends far beyond mechanical support alone and includes
interactions through coagulation cascade proteins. Here, we systematically review the …

Diabetic peripheral neuropathy (DPN) is a disabling common complication of diabetes
mellitus (DM). Thrombin, a coagulation factor, is increased in DM and affects nerve function …

The cell surface protease-activated receptor 1 (PAR1) is overexpressed in glioblastoma
multiforme (GBM). We studied the function and structure of intracellular microtubule (MT) …

Glia cells are involved in upper motor neuron degeneration in amyotrophic lateral sclerosis
(ALS). Protease activated receptor 1 (PAR1) pathway is related to brain pathologies. Brain …

The aim of this study was to characterize the distribution of the thrombin receptor, protease
activated receptor 1 (PAR1), in the neuroretina. Neuroretina samples of wild-type C57BL/6J …

Thrombin is present in peripheral nerves and is involved in the pathogenesis of neuropathy.
We evaluated thrombin activity in skin punch biopsies taken from the paws of male mice and …

Background: Neural inflammation is linked to coagulation. Low levels of thrombin have a
neuroprotective effect, mediated by activated protein C (APC). We describe a sensitive novel …

Diabetic encephalopathy (DE) is an inflammation-associated diabetes mellitus (DM)
complication. Inflammation and coagulation are linked and are both potentially modulated …