p38 MAPK signaling in osteoblast differentiation
E Rodríguez-Carballo, B Gámez… - Frontiers in cell and …, 2016 - frontiersin.org
The skeleton is a highly dynamic tissue whose structure relies on the balance between bone
deposition and resorption. This equilibrium, which depends on osteoblast and osteoclast …
deposition and resorption. This equilibrium, which depends on osteoblast and osteoclast …
Parathyroid hormone and its related peptides in bone metabolism
T Chen, Y Wang, Z Hao, Y Hu, J Li - Biochemical pharmacology, 2021 - Elsevier
Parathyroid hormone (PTH) is an 84-amino-acid peptide hormone that is secreted by the
parathyroid gland. It has different administration modes in bone tissue through which it …
parathyroid gland. It has different administration modes in bone tissue through which it …
The roles of circRNA–miRNA–mRNA networks in the development and treatment of osteoporosis
M Gao, Z Zhang, J Sun, B Li, Y Li - Frontiers in endocrinology, 2022 - frontiersin.org
Osteoporosis is a systemic metabolic disease, mainly characterized by reduced bone
mineral density and destruction of bone tissue microstructure. However, the molecular …
mineral density and destruction of bone tissue microstructure. However, the molecular …
PTH and the Regulation of Mesenchymal Cells within the Bone Marrow Niche
H Liu, L Liu, CJ Rosen - Cells, 2024 - mdpi.com
Parathyroid hormone (PTH) plays a pivotal role in maintaining calcium homeostasis, largely
by modulating bone remodeling processes. Its effects on bone are notably dependent on the …
by modulating bone remodeling processes. Its effects on bone are notably dependent on the …
PDGF Receptor Signaling in Osteoblast Lineage Cells Controls Bone Resorption Through Upregulation of Csf1 Expression
J Brun, CM Andreasen, C Ejersted… - Journal of Bone and …, 2020 - academic.oup.com
The physiological functions of platelet‐derived growth factor receptors (PDGFRs) α and β in
osteoblast biology and bone metabolism remain to be established. Here, we show that …
osteoblast biology and bone metabolism remain to be established. Here, we show that …
Dynamic balance between pth1r-dependent signal cascades determines its pro-or anti-osteogenic effects on MSC
K Kulebyakin, P Tyurin-Kuzmin, L Sozaeva, N Voloshin… - Cells, 2022 - mdpi.com
Parathyroid hormone (PTH) is one of the key regulators of calcium and phosphate
metabolism in the body, controlling bone metabolism and ion excretion by the kidneys. At …
metabolism in the body, controlling bone metabolism and ion excretion by the kidneys. At …
Adiponectin as Well as Compressive Forces Regulate in vitro β-Catenin Expression on Cementoblasts via Mitogen-Activated Protein Kinase Signaling Activation
J Yong, J Von Bremen, G Ruiz-Heiland… - Frontiers in Cell and …, 2021 - frontiersin.org
We aimed to investigate the molecular effect that adiponectin exerts on cementoblasts
especially in the presence of compressive forces. OCCM-30 cells (M. Somerman, NIH …
especially in the presence of compressive forces. OCCM-30 cells (M. Somerman, NIH …
[HTML][HTML] Sclerostin blockade inhibits bone resorption through PDGF receptor signaling in osteoblast lineage cells
C Thouverey, P Apostolides, J Brun, J Caverzasio… - JCI insight, 2024 - ncbi.nlm.nih.gov
While sclerostin-neutralizing antibodies (Scl-Abs) transiently stimulate bone formation by
activating Wnt signaling in osteoblast lineage cells, they exert sustained inhibition of bone …
activating Wnt signaling in osteoblast lineage cells, they exert sustained inhibition of bone …
Heterotrimeric G proteins in the control of parathyroid hormone actions
Parathyroid hormone (PTH) is a key regulator of skeletal physiology and calcium and
phosphate homeostasis. It acts on bone and kidney to stimulate bone turnover, increase the …
phosphate homeostasis. It acts on bone and kidney to stimulate bone turnover, increase the …
Anabolic actions of PTH in murine models: two decades of insights
LE Zweifler, AJ Koh, S Daignault‐Newton… - Journal of Bone and …, 2020 - academic.oup.com
Parathyroid hormone (PTH) is produced by the parathyroid glands in response to low serum
calcium concentrations where it targets bones, kidneys, and indirectly, intestines. The N …
calcium concentrations where it targets bones, kidneys, and indirectly, intestines. The N …